4-羟基-2(1H)-喹啉酮合成路线 （共 93 条）
反应条件
sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride in toluene T=50°C; 88 h; MechanismProduct distribution;
参考文献
Reisch, Johannes; Bathe, Andreas; Salehi-Artimani, Reza A.
Archiv der Pharmazie (Weinheim, Germany), 1986 , vol. 319, # 8 p. 720 - 727
参考文献
Reisch, Johannes; Bathe, Andreas; Rosenthal, Bernd H. W.; Salehi-Artimani, Reza A.
Journal of Heterocyclic Chemistry, 1987 , vol. 24, p. 869 - 872
反应条件
1: 4-hydroxyquinolin-2(1H)-one With sodium hydroxide in water T=4 - 80°C; 2: chloroform in water T=80°C; Reimer-Tiemann reaction; 13.6667 h; 3: With sulfuric acid in water T=20°C;
参考文献
Bhudevi; Ramana; Mudiraj, Anwita; Reddy
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2009 , vol. 48, # 2 p. 255 - 260
反应条件
1: 91 percent / ethane-1,2-diol / 190 °C 2: 93 percent / 2 N aq. NaOH / dioxane / 2 h / 100 °C View Scheme
参考文献
Fiala, Werner; Stadlbauer, Wolfgang
Journal fuer Praktische Chemie/Chemiker-Zeitung, 1993 , vol. 335, # 2 p. 128 - 134
反应条件
nitric acid 1.) RT, 10 min, 2.) 75 deg C, 12 min;
参考文献
Riker Laboratories, Inc.
Patent: US5756747 A1, 1998 ;
反应条件
iodine; sodium carbonate in 1,4-dioxane; water 22 h; Heating;
参考文献
Snider, Barry B.; Wu, Xiaoxing
Heterocycles, 2006 , vol. 70, p. 279 - 294
反应条件
in benzene T=65°C; 2 h;
参考文献
Abd El-Nabi, Hisham A.
Organic Preparations and Procedures International, 1997 , vol. 29, # 2 p. 211 - 214
反应条件
1: 4-hydroxyquinolin-2(1H)-one With triethylamine in N,N-dimethyl-formamide T=20°C; 0.0833333 h; 2: N,N-bis(trifluoromethanesulfonyl)aniline in N,N-dimethyl-formamide T=20°C; 15 h;
参考文献
Voss, Felix; Herdtweck, Eberhardt; Bach, Thorsten
Chemical Communications, 2011 , vol. 47, # 7 p. 2137 - 2139
反应条件
1: 3.4 g / K2CO3 / acetone / 240 h / Heating 2: 1.2 g / m-chloroperbenzoic acid / CHCl3 / 120 h / Ambient temperature 3: 1.0 g / 24 h / Ambient temperature 4: 0.8 g / aq. KOH / methanol / 6 h / Ambient temperature View Scheme
参考文献
Grundon Michael F.; Ramachandran, V. N.; Donnelly, Michael E.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1981 , p. 633 - 635
反应条件
1: 85 percent / benzene / 2 h / 65 °C 2: 83 percent / acetone / 2 h View Scheme
参考文献
Organic Preparations and Procedures International, , vol. 29, # 2 p. 211 - 214
