sodium methylate; palladium monocarbide in hydrogen

1: acetoacetic acid methyl ester With sodium methylate in methanol T=0°C; 2: 1-bromo-hexane in methanol T=50°C; Further stages.;

anhydrous cobalt diacetate in acetic acid T=75 - 80°C; 30 h;

oxygen; anhydrous cobalt diacetate in acetic acid T=80°C; 14 h;

暂无反应条件数据

oxygen; anhydrous cobalt diacetate in acetic acid T=65°C; stereoselectivity; also with other terminal olefins;

1: 48 percent / 1.) NaH; 2.) BuLi / tetrahydrofuran; hexane / 1.) 1 h, room t.; 2.) 0 degC, 15 min, room t., 1 h 2: 94 percent / TsOH / CH2Cl2 / 0 degC, 30 min, room t., 1 h 3: 0.67 g / NaBH4 / methanol; tetrahydrofuran / 1 h / Ambient temperature 4: 0.61 g / NaOH / H2O; methanol / 4 h / Heating 5: benzenesulfonyl chlorid / pyridine / 0.25 h / 0 °C View Scheme

1: 48 percent / 1.) NaH; 2.) BuLi / tetrahydrofuran; hexane / 1.) 1 h, room t.; 2.) 0 degC, 15 min, room t., 1 h 2: 94 percent / TsOH / CH2Cl2 / 0 degC, 30 min, room t., 1 h 3: 0.67 g / NaBH4 / methanol; tetrahydrofuran / 1 h / Ambient temperature 4: 0.61 g / NaOH / H2O; methanol / 4 h / Heating 5: benzenesulfonyl chlorid / pyridine / 0.25 h / 0 °C 6: pyridinium p-toluenesulfonate / ethanol / 4 h / 55 °C 7: 26 percent / triphenylphosphine, diethyl azodicarboxylate / tetrahydrofuran / Ambient temperature View Scheme

methanol; sodium bromide electrolysis;