(2R)-2-氨甲酰基吡咯烷-1-甲酸叔丁酯合成路线 （共 5 条）
反应条件
1: With 4-methyl-morpholine; isobutyl chloroformate in tetrahydrofuran T=-78°C; 1 h; 2: With ammonia in tetrahydrofuran; water T=-78 - 20°C; 2 h;
参考文献
AstraZeneca AB; NPS PHARMACEUTICALS, INC.
Patent: US2007/259926 A1, 2007 ;
Location in patent: Page/Page column 9 ;
US 20070259926 A1
反应条件
ammonia in tetrahydrofuran; water T=60°C; 18 h; Inert atmosphere;
参考文献
Journal of Medicinal Chemistry, , vol. 52, # 21 p. 6672 - 6684
反应条件
zirconium tetrachloride; ammonium carbamate in toluene T=120°C; 24 h; Inert atmosphereMolecular sieve; Overall yield = 89 percent;
参考文献
Advanced Synthesis and Catalysis, , vol. 354, # 13 p. 2531 - 2536
反应条件
1: With trifluoroacetic acid T=25°C; 2: With N-ethyl-N,N-diisopropylamine in dichloromethane T=25°C;
参考文献
Bioorganic and Medicinal Chemistry, , vol. 18, # 7 p. 2720 - 2727
反应条件
2,4,6-trichloro-1,3,5-triazine in N,N-dimethyl-formamide 1 h;
参考文献
AstraZeneca AB; NPS PHARMACEUTICALS, INC.
Patent: US2007/259926 A1, 2007 ;
Location in patent: Page/Page column 9 ;
US 20070259926 A1
