2-氯-9-甲基-9h-嘌呤-6-胺合成路线 （共 8 条）
反应条件
1: 47 percent Spectr. / Na, liq. NH3 / diethyl ether / 0.5 h 2: 46 percent Spectr. / Na, liq. NH3 / 1 h / variation of reaction time; other 6-amino- and 6-alkylamino-9-alkylpurines View Scheme
参考文献
Kos, Nico J.; Plas, Henk C. van der
Journal of Organic Chemistry, 1981 , vol. 46, # 24 p. 5000 - 5003
反应条件
ammonia; sodium in diethyl ether 0.5 h;
参考文献
Kos, Nico J.; Plas, Henk C. van der
Journal of Organic Chemistry, 1981 , vol. 46, # 24 p. 5000 - 5003
反应条件
ammonia; sodium in diethyl ether 0.5 h;
参考文献
Journal of Organic Chemistry, , vol. 46, # 24 p. 5000 - 5003
反应条件
ammonium hydroxide in acetonitrile
T=55°C; 5.5 h;
参考文献
Joerg, Manuela; Shonberg, Jeremy; Mak, Frankie S.; Miller, Neil D.; Yuriev, Elizabeth; Scammells, Peter J.; Capuano, Ben
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 11 p. 3427 - 3433
反应条件
potassium carbonate in N,N-dimethyl-formamide
参考文献
Thompson, Robert D.; Secunda, Sherrie; Daly, John W.; Olsson, Ray A.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 9 p. 2877 - 2882
反应条件
1: N,N-diisopropylethylamine, NH3 / propan-1-ol / 20 h / Heating
2: K2CO3 / dimethylformamide
View Scheme
参考文献
Thompson, Robert D.; Secunda, Sherrie; Daly, John W.; Olsson, Ray A.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 9 p. 2877 - 2882
参考文献
Falconer et al.
Journal of the Chemical Society, 1939 , p. 1784,1786
反应条件
1: ethanol / 130 °C
2: PH4I; aqueous HI
View Scheme
参考文献
Falconer et al.
Journal of the Chemical Society, 1939 , p. 1784,1786
