1-溴-4-(1,1-二甲基庚基)-2-(苯基甲氧基)-苯合成路线 （共 13 条）
反应条件
1: Mg / tetrahydrofuran / 20 h / Heating
2: CuI / tetrahydrofuran / 0.5 h / -3 °C
View Scheme
参考文献
Melvin, Lawrence S.; Johnson, M. Ross; Harbert, Charles A.; Milne, George M.; Weissman, Albert
Journal of Medicinal Chemistry, 1984 , vol. 27, # 1 p. 67 - 71
反应条件
1: Mg / tetrahydrofuran / 20 h / Heating
2: CuI / tetrahydrofuran / 0.5 h / -3 °C
3: 62 percent / H2, NaHCO3 / 10percent Pd/C / ethanol / 2 h / 760 Torr
View Scheme
参考文献
Pfizer Inc.
Patent: DE2839836 , 1979 ;
Chem.Abstr., 1979 , vol. 91, # 20099
反应条件
1: Mg / tetrahydrofuran / 20 h / Heating
2: CuI / tetrahydrofuran / 0.5 h / -3 °C
3: 51 percent / NaBH4 / methanol; tetrahydrofuran / 1 h / -40 °C
4: 77 percent / H2, NaHCO3 / 10percent Pd/C / ethanol / 2 h / 760 Torr
View Scheme
参考文献
Pfizer Inc.
Patent: DE2839836 , 1979 ;
Chem.Abstr., 1979 , vol. 91, # 20099
