1-溴-4-(1,1-二甲基庚基)-2-(苯基甲氧基)-苯合成路线 （共 13 条）
反应条件
bromine; sodium sulfite in dichloromethane
参考文献
Pfizer Inc.
Patent: US4285867 A1, 1981 ;
反应条件
potassium hydride
1.) DMF, -18 deg C, 15 min, 2.) 25 deg C, 30 min; Multistep reaction;
参考文献
Melvin, Lawrence S.; Johnson, M. Ross; Harbert, Charles A.; Milne, George M.; Weissman, Albert
Journal of Medicinal Chemistry, 1984 , vol. 27, # 1 p. 67 - 71
反应条件
1: 57 percent / DMSO, NaOH / 4 h / 15 °C
2: 78 percent / H2 / 10percent Pd/C / ethanol / 13 h / 2585.7 Torr
3: 100 percent / Br2 / CCl4 / 0.25 h / 30 °C
4: 1.) KH / 1.) DMF, -18 deg C, 15 min, 2.) 25 deg C, 30 min
View Scheme
参考文献
Melvin, Lawrence S.; Johnson, M. Ross; Harbert, Charles A.; Milne, George M.; Weissman, Albert
Journal of Medicinal Chemistry, 1984 , vol. 27, # 1 p. 67 - 71
反应条件
1: 1.) diisobutylaluminium hydride (DIBAL), 2.) aq. H2SO4 / 1.) THF, hexane, 25 deg C, 2 h, 2.) THF, hexane, 25 deg C, 2 h
2: 57 percent / DMSO, NaOH / 4 h / 15 °C
3: 78 percent / H2 / 10percent Pd/C / ethanol / 13 h / 2585.7 Torr
4: 100 percent / Br2 / CCl4 / 0.25 h / 30 °C
5: 1.) KH / 1.) DMF, -18 deg C, 15 min, 2.) 25 deg C, 30 min
View Scheme
参考文献
Melvin, Lawrence S.; Johnson, M. Ross; Harbert, Charles A.; Milne, George M.; Weissman, Albert
Journal of Medicinal Chemistry, 1984 , vol. 27, # 1 p. 67 - 71
反应条件
1: 78 percent / H2 / 10percent Pd/C / ethanol / 13 h / 2585.7 Torr
2: 100 percent / Br2 / CCl4 / 0.25 h / 30 °C
3: 1.) KH / 1.) DMF, -18 deg C, 15 min, 2.) 25 deg C, 30 min
View Scheme
参考文献
Melvin, Lawrence S.; Johnson, M. Ross; Harbert, Charles A.; Milne, George M.; Weissman, Albert
Journal of Medicinal Chemistry, 1984 , vol. 27, # 1 p. 67 - 71
反应条件
1: 57 percent / DMSO, NaOH / 4 h / 15 °C
2: 78 percent / H2 / 10percent Pd/C / ethanol / 13 h / 2585.7 Torr
3: 100 percent / Br2 / CCl4 / 0.25 h / 30 °C
4: 1.) KH / 1.) DMF, -18 deg C, 15 min, 2.) 25 deg C, 30 min
View Scheme
参考文献
Melvin, Lawrence S.; Johnson, M. Ross; Harbert, Charles A.; Milne, George M.; Weissman, Albert
Journal of Medicinal Chemistry, 1984 , vol. 27, # 1 p. 67 - 71
反应条件
1: 100 percent / Br2 / CCl4 / 0.25 h / 30 °C
2: 1.) KH / 1.) DMF, -18 deg C, 15 min, 2.) 25 deg C, 30 min
View Scheme
参考文献
Melvin, Lawrence S.; Johnson, M. Ross; Harbert, Charles A.; Milne, George M.; Weissman, Albert
Journal of Medicinal Chemistry, 1984 , vol. 27, # 1 p. 67 - 71
反应条件
1: Mg / tetrahydrofuran / 20 h / Heating
2: CuI / tetrahydrofuran / 0.5 h / -3 °C
View Scheme
参考文献
Melvin, Lawrence S.; Johnson, M. Ross; Harbert, Charles A.; Milne, George M.; Weissman, Albert
Journal of Medicinal Chemistry, 1984 , vol. 27, # 1 p. 67 - 71
反应条件
1: Mg / tetrahydrofuran / 20 h / Heating
2: CuI / tetrahydrofuran / 0.5 h / -3 °C
3: 35 percent / H2, NaHCO3 / 10percent Pd/C / ethanol / 2 h / 760 Torr
View Scheme
参考文献
Melvin, Lawrence S.; Johnson, M. Ross; Harbert, Charles A.; Milne, George M.; Weissman, Albert
Journal of Medicinal Chemistry, 1984 , vol. 27, # 1 p. 67 - 71
反应条件
(i) Mg, (ii) CuI, (iii) /BRN= 1280477/; Multistep reaction;
参考文献
Pfizer Inc.
Patent: US4306097 A1, 1981 ;
