3-(1,1-二甲基庚基)苯酚合成路线 （共 13 条）
反应条件
1: 100 percent / Br2 / CCl4 / 0.25 h / 30 °C
2: 1.) KH / 1.) DMF, -18 deg C, 15 min, 2.) 25 deg C, 30 min
3: Mg / tetrahydrofuran / 20 h / Heating
4: CuI / tetrahydrofuran / 0.5 h / -3 °C
View Scheme
参考文献
Melvin, Lawrence S.; Johnson, M. Ross; Harbert, Charles A.; Milne, George M.; Weissman, Albert
Journal of Medicinal Chemistry, 1984 , vol. 27, # 1 p. 67 - 71
反应条件
1: 100 percent / Br2 / CCl4 / 0.25 h / 30 °C
2: 1.) KH / 1.) DMF, -18 deg C, 15 min, 2.) 25 deg C, 30 min
3: Mg / tetrahydrofuran / 20 h / Heating
4: CuI / tetrahydrofuran / 0.5 h / -3 °C
5: 62 percent / H2, NaHCO3 / 10percent Pd/C / ethanol / 2 h / 760 Torr
View Scheme
参考文献
Melvin, Lawrence S.; Johnson, M. Ross; Harbert, Charles A.; Milne, George M.; Weissman, Albert
Journal of Medicinal Chemistry, 1984 , vol. 27, # 1 p. 67 - 71
反应条件
1: 100 percent / Br2 / CCl4 / 0.25 h / 30 °C
2: 1.) KH / 1.) DMF, -18 deg C, 15 min, 2.) 25 deg C, 30 min
3: Mg / tetrahydrofuran / 20 h / Heating
4: CuI / tetrahydrofuran / 0.5 h / -3 °C
5: 51 percent / NaBH4 / methanol; tetrahydrofuran / 1 h / -40 °C
6: 77 percent / H2, NaHCO3 / 10percent Pd/C / ethanol / 2 h / 760 Torr
View Scheme
参考文献
Melvin, Lawrence S.; Johnson, M. Ross; Harbert, Charles A.; Milne, George M.; Weissman, Albert
Journal of Medicinal Chemistry, 1984 , vol. 27, # 1 p. 67 - 71
