3-(1,1-二甲基庚基)苯酚合成路线 （共 13 条）
反应条件
1: With boron tribromide in dichloromethane
2 h;
2: With water in dichloromethane
参考文献
Selwood, David; Visintin, Cristina; Baker, David; Pryce, Gareth; Okuyama, Masahiro
Patent: US2008/262011 A1, 2008 ;
Location in patent: Page/Page column 15; 13 ;
US 20080262011 A1
反应条件
hydrogen; palladium on activated charcoal in ethanol
P=2585.7 Torr; 13 h;
参考文献
Melvin, Lawrence S.; Johnson, M. Ross; Harbert, Charles A.; Milne, George M.; Weissman, Albert
Journal of Medicinal Chemistry, 1984 , vol. 27, # 1 p. 67 - 71
反应条件
1: NaH / dimethylsulfoxide
2: H2 / Pd/C
View Scheme
参考文献
Worm, Karin; Zhou, Q. Jean; Stabley, Gabriel J.; DeHaven, Robert N.; Dolle, Roland E.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 13 p. 3652 - 3656
反应条件
1: DIBAL-H; aq. H2SO4
2: NaH / dimethylsulfoxide
3: H2 / Pd/C
View Scheme
参考文献
Worm, Karin; Zhou, Q. Jean; Stabley, Gabriel J.; DeHaven, Robert N.; Dolle, Roland E.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 13 p. 3652 - 3656
反应条件
1: NaH / dimethylsulfoxide
2: H2 / Pd/C
View Scheme
参考文献
Worm, Karin; Zhou, Q. Jean; Stabley, Gabriel J.; DeHaven, Robert N.; Dolle, Roland E.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 13 p. 3652 - 3656
反应条件
hydrogen; palladium on activated charcoal
参考文献
Worm, Karin; Zhou, Q. Jean; Stabley, Gabriel J.; DeHaven, Robert N.; Dolle, Roland E.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 13 p. 3652 - 3656
反应条件
1: 100 percent / Br2 / CCl4 / 0.25 h / 30 °C
2: 1.) KH / 1.) DMF, -18 deg C, 15 min, 2.) 25 deg C, 30 min
3: Mg / tetrahydrofuran / 20 h / Heating
4: CuI / tetrahydrofuran / 0.5 h / -3 °C
View Scheme
参考文献
Melvin, Lawrence S.; Johnson, M. Ross; Harbert, Charles A.; Milne, George M.; Weissman, Albert
Journal of Medicinal Chemistry, 1984 , vol. 27, # 1 p. 67 - 71
反应条件
1: 100 percent / Br2 / CCl4 / 0.25 h / 30 °C
2: 1.) KH / 1.) DMF, -18 deg C, 15 min, 2.) 25 deg C, 30 min
3: Mg / tetrahydrofuran / 20 h / Heating
4: CuI / tetrahydrofuran / 0.5 h / -3 °C
5: 35 percent / H2, NaHCO3 / 10percent Pd/C / ethanol / 2 h / 760 Torr
View Scheme
参考文献
Melvin, Lawrence S.; Johnson, M. Ross; Harbert, Charles A.; Milne, George M.; Weissman, Albert
Journal of Medicinal Chemistry, 1984 , vol. 27, # 1 p. 67 - 71
反应条件
bromine in tetrachloromethane
T=30°C; 0.25 h;
参考文献
Melvin, Lawrence S.; Johnson, M. Ross; Harbert, Charles A.; Milne, George M.; Weissman, Albert
Journal of Medicinal Chemistry, 1984 , vol. 27, # 1 p. 67 - 71
反应条件
1: 100 percent / Br2 / CCl4 / 0.25 h / 30 °C
2: 1.) KH / 1.) DMF, -18 deg C, 15 min, 2.) 25 deg C, 30 min
View Scheme
参考文献
Melvin, Lawrence S.; Johnson, M. Ross; Harbert, Charles A.; Milne, George M.; Weissman, Albert
Journal of Medicinal Chemistry, 1984 , vol. 27, # 1 p. 67 - 71
