2-[3-(苄氧基)苯基]-2-甲基丙腈合成路线 （共 14 条）
反应条件
sodium hydroxide in dimethyl sulfoxide
T=50°C; 1.5 h;
参考文献
Adolor Corporation
Patent: US2006/74086 A1, 2006 ;
Location in patent: Page/Page column 26 ;
US 20060074086 A1
反应条件
sodium hydroxide in water; dimethyl sulfoxide
T=0 - 20°C; 3 h;
参考文献
TAKEDA CHEMICAL INDUSTRIES, LTD.
Patent: WO2003/99793 A1, 2003 ;
Location in patent: Page 158 ;
反应条件
sodium hydroxide in water; dimethyl sulfoxide
参考文献
Pfizer Inc.
Patent: US4283569 A1, 1981 ;
反应条件
sodium hydroxide in water; dimethyl sulfoxide
参考文献
Pfizer Inc.
Patent: US4306097 A1, 1981 ;
反应条件
1: 1.) diisobutylaluminium hydride (DIBAL), 2.) aq. H2SO4 / 1.) THF, hexane, 25 deg C, 2 h, 2.) THF, hexane, 25 deg C, 2 h
2: 57 percent / DMSO, NaOH / 4 h / 15 °C
3: 78 percent / H2 / 10percent Pd/C / ethanol / 13 h / 2585.7 Torr
4: 100 percent / Br2 / CCl4 / 0.25 h / 30 °C
5: 1.) KH / 1.) DMF, -18 deg C, 15 min, 2.) 25 deg C, 30 min
6: Mg / tetrahydrofuran / 20 h / Heating
7: CuI / tetrahydrofuran / 0.5 h / -3 °C
View Scheme
参考文献
Melvin, Lawrence S.; Johnson, M. Ross; Harbert, Charles A.; Milne, George M.; Weissman, Albert
Journal of Medicinal Chemistry, 1984 , vol. 27, # 1 p. 67 - 71
反应条件
1: 1.) diisobutylaluminium hydride (DIBAL), 2.) aq. H2SO4 / 1.) THF, hexane, 25 deg C, 2 h, 2.) THF, hexane, 25 deg C, 2 h
2: 57 percent / DMSO, NaOH / 4 h / 15 °C
3: 78 percent / H2 / 10percent Pd/C / ethanol / 13 h / 2585.7 Torr
4: 100 percent / Br2 / CCl4 / 0.25 h / 30 °C
5: 1.) KH / 1.) DMF, -18 deg C, 15 min, 2.) 25 deg C, 30 min
6: Mg / tetrahydrofuran / 20 h / Heating
7: CuI / tetrahydrofuran / 0.5 h / -3 °C
8: 35 percent / H2, NaHCO3 / 10percent Pd/C / ethanol / 2 h / 760 Torr
View Scheme
参考文献
Melvin, Lawrence S.; Johnson, M. Ross; Harbert, Charles A.; Milne, George M.; Weissman, Albert
Journal of Medicinal Chemistry, 1984 , vol. 27, # 1 p. 67 - 71
反应条件
1: With diisobutylaluminium hydride in tetrahydrofuran; hexane
T=15 - 20°C; 2 h;
2: With sulfuric acid in tetrahydrofuran; hexane; water
T=30°C; 2 h;
参考文献
Adolor Corporation
Patent: US2006/74086 A1, 2006 ;
Location in patent: Page/Page column 26 ;
US 20060074086 A1
反应条件
1: DIBAL-H; aq. H2SO4
2: NaH / dimethylsulfoxide
3: H2 / Pd/C
View Scheme
参考文献
Melvin, Lawrence S.; Johnson, M. Ross; Harbert, Charles A.; Milne, George M.; Weissman, Albert
Journal of Medicinal Chemistry, 1984 , vol. 27, # 1 p. 67 - 71
反应条件
1: DIBAL-H; aq. H2SO4
2: NaH / dimethylsulfoxide
3: H2 / Pd/C
4: Br2 / CCl4
View Scheme
参考文献
Melvin, Lawrence S.; Johnson, M. Ross; Harbert, Charles A.; Milne, George M.; Weissman, Albert
Journal of Medicinal Chemistry, 1984 , vol. 27, # 1 p. 67 - 71
反应条件
1: 1.) diisobutylaluminium hydride (DIBAL), 2.) aq. H2SO4 / 1.) THF, hexane, 25 deg C, 2 h, 2.) THF, hexane, 25 deg C, 2 h
2: 57 percent / DMSO, NaOH / 4 h / 15 °C
3: 78 percent / H2 / 10percent Pd/C / ethanol / 13 h / 2585.7 Torr
4: 100 percent / Br2 / CCl4 / 0.25 h / 30 °C
5: 1.) KH / 1.) DMF, -18 deg C, 15 min, 2.) 25 deg C, 30 min
View Scheme
参考文献
Melvin, Lawrence S.; Johnson, M. Ross; Harbert, Charles A.; Milne, George M.; Weissman, Albert
Journal of Medicinal Chemistry, 1984 , vol. 27, # 1 p. 67 - 71
