9-(2-氯-6-氟苄基)-6-甲基氨基嘌呤合成路线 (共 9 条)
反应条件
potassium carbonate in N,N-dimethyl acetamide; water
参考文献
Takeda Chemical Industries, Ltd.
Patent: US4189485 A1, 1980 ;
反应条件
sodium hydroxide in acetone
参考文献
Kohjin Co., Ltd.
Patent: US4900826 A1, 1990 ;
反应条件
sodium hydroxide in acetone
参考文献
Kohjin Co., Ltd.
Patent: US4900826 A1, 1990 ;
反应条件
sodium hydroxide in ethanol; acetone
参考文献
Kohjin Co., Ltd.
Patent: US4900826 A1, 1990 ;
参考文献
Kohjin Co., Ltd.
Patent: US4900826 A1, 1990 ;
参考文献
Imai; Seo
European Journal of Medicinal Chemistry, 1980 , vol. 15, # 3 p. 207 - 210
反应条件
1: 63 percent / 1,2-dimethoxy-ethane / 10 h / Ambient temperature
2: 251 mg / sodium hydroxide / methanol / 5 h / Ambient temperature
View Scheme
参考文献
Imai; Seo
European Journal of Medicinal Chemistry, 1980 , vol. 15, # 3 p. 207 - 210
反应条件
sodium hydroxide in methanol
5 h; Ambient temperature;
参考文献
Imai; Seo
European Journal of Medicinal Chemistry, 1980 , vol. 15, # 3 p. 207 - 210
反应条件
1: 67 percent / phosphoryl chloride, tripropyl amine / 0.67 h / Heating
2: 73 percent / 110 - 120 °C
View Scheme
参考文献
Imai; Seo
European Journal of Medicinal Chemistry, 1980 , vol. 15, # 3 p. 207 - 210