2-羟甲基-18-冠-6合成路线 （共 13 条）
反应条件
hydrogen; palladium on activated charcoal in ethanol P=760 Torr; 48 h; Ambient temperature;
参考文献
Weber, Edwin
Liebigs Annalen der Chemie, 1983 , # 5 p. 770 - 801
反应条件
perchloric acid; palladium on activated charcoal in ethanol T=80°C; 24 h;
参考文献
Ikeda, Isao; Emura, Hiroshi; Okahara, Mitsuo
Synthesis, 1984 , # 1 p. 73 - 74
反应条件
lithium aluminium tetrahydride in diethyl ether 1.) room temperature, 3 h 2.) reflux 1 h;
参考文献
Fukunishi, Koji; Czech, Bronislaw; Regen, Steven L.
Journal of Organic Chemistry, 1981 , vol. 46, # 6 p. 1218 - 1221
反应条件
1: 55 percent / NaH (80percent in paraffine oil) / tetrahydrofuran / 12 h / Heating 2: 94 percent / H2, Pd/C (10percent) / ethanol / 4 h / Ambient temperature View Scheme
参考文献
Liebigs Annalen der Chemie, , # 5 p. 770 - 801
反应条件
1: KH / tetrahydrofuran / 1.) 3h, 2.) 15h, RT; 24h, reflux 2: 48.1 percent / Pd/C, TsOH / methanol; H2O / 24 h / Heating View Scheme
参考文献
Journal of Organic Chemistry, , vol. 48, # 7 p. 1116 - 1120
反应条件
1: 1.) KOH, 2.) KOH, TosCl / 1.) 1 h, 80 deg C, 2.) dioxan, 4 h, reflux 2: 79 percent / 70percent HClO4 / 5percent Pd/C / aq. ethanol / 24 h / 80 °C View Scheme
参考文献
Synthesis, , # 1 p. 73 - 74
反应条件
1: 52 percent / KOH / dioxane / 18 h / 80 °C 2: hydrogen, p-toluenesulphonic acid / Pd/C / 25 °C / 7500.6 Torr View Scheme
参考文献
Collection of Czechoslovak Chemical Communications, , vol. 52, # 10 p. 2500 - 2507
反应条件
1: 52 percent / KOH / dioxane / 18 h / 80 °C 2: hydrogen, p-toluenesulphonic acid / Pd/C / 25 °C / 7500.6 Torr View Scheme
参考文献
Collection of Czechoslovak Chemical Communications, , vol. 52, # 10 p. 2500 - 2507
反应条件
di-tert-butyl peroxide in water T=125°C; 14 h;
参考文献
Journal fuer Praktische Chemie (Leipzig), , vol. 332, # 5 p. 719 - 722
反应条件
1: 76 percent / 1M H2SO4 / acetone / 0.75 h / Heating 2: 99 percent / LiAlH4 / diethyl ether / 1.) room temperature, 3 h 2.) reflux 1 h View Scheme
参考文献
Journal of Organic Chemistry, , vol. 46, # 6 p. 1218 - 1221
