di-isopropyl azodicarboxylate; triphenylphosphine in toluene T=220°C; Mitsunobu reaction-Claisen rearrangement; 0.5 h; microwave irradiation;

trimethylsilyl iodide in chloroform 1 h; Ambient temperature;

1: 1.) n-BuLi, 2.) I2 / 1.) THF, hexane, from -10 deg C to RT, 2 h, 2.) THF, 20 deg C, 2 h 2: 50 percent / Pd(OAc)2, n-Bu4NCl, KOAc, PPh3 / dimethylformamide / 72 h / 80 °C 3: 65 percent / trimethylsilyl iodide / CHCl3 / 1 h / Ambient temperature View Scheme

1: 50 percent / Pd(OAc)2, n-Bu4NCl, KOAc, PPh3 / dimethylformamide / 72 h / 80 °C 2: 65 percent / trimethylsilyl iodide / CHCl3 / 1 h / Ambient temperature View Scheme