1: With sodium hydroxide in water 2: With hydrogenchloride in water; isopropyl alcohol Product distribution / selectivity;

1: 43 percent / methanesulfonic acid / toluene / 2 h / Heating 2: H2; (R)-(S)-1-Ph3P-2-(CHMeP(t-Bu)2)ferrocene; Et3N / [(p-cymene)RuCl2]2 / ethanol; 1,2-dichloro-ethane / 24 h / 25 °C / 4654.33 Torr View Scheme

1: 43 percent / methanesulfonic acid / toluene / 2 h / Heating 2: H2; (R)-(S)-1-Ph3P-2-(CHMeP(t-Bu)2)ferrocene; Et3N / [(p-cymene)RuCl2]2 / ethanol; 1,2-dichloro-ethane / 24 h / 25 °C / 4654.33 Torr View Scheme