1,4-二[[2-(二甲基氨基)乙基]氨基]-9,10-蒽二酮合成路线 （共 14 条）
反应条件
in dimethyl sulfoxide
44 h; Ambient temperature;
参考文献
Krapcho, A. Paul; Getahun, Zelleka; Avery, Kenneth L.; Vargas, Kevin J.; Hacker, Miles P.; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 8 p. 2373 - 2380
反应条件
1: 80 percent / diethylamine / diethyl ether
2: 1.) n-BuLi / 1.) THF, -78 deg C, 1 h, 2.) -65 deg C, 15 min
3: H2SO4 / H2O / 1 h / Heating
4: 130 °C / 0.05 Torr
5: 89 percent / AlCl3, NaCl / 1.5 h / 220 °C
6: 78 percent / pyridine / 48 h / Ambient temperature
View Scheme
参考文献
Krapcho, A. Paul; Getahun, Zelleka; Avery, Kenneth J.
Synthetic Communications, 1990 , vol. 20, # 14 p. 2139 - 2146
反应条件
1: 1.) n-BuLi / 1.) THF, -78 deg C, 1 h, 2.) -65 deg C, 15 min
2: H2SO4 / H2O / 1 h / Heating
3: 130 °C / 0.05 Torr
4: 89 percent / AlCl3, NaCl / 1.5 h / 220 °C
5: 78 percent / pyridine / 48 h / Ambient temperature
View Scheme
参考文献
Krapcho, A. Paul; Getahun, Zelleka; Avery, Kenneth J.
Synthetic Communications, 1990 , vol. 20, # 14 p. 2139 - 2146
反应条件
pyridine
48 h; Ambient temperature;
参考文献
Krapcho, A. Paul; Getahun, Zelleka; Avery, Kenneth J.
Synthetic Communications, 1990 , vol. 20, # 14 p. 2139 - 2146
反应条件
1: 84 percent / trifluoroperacetic acid / CH2Cl2 / 2 h / Heating
2: 35 percent / 48 h / Ambient temperature
View Scheme
参考文献
Krapcho, A. Paul; Avery, Kenneth L.
Journal of Organic Chemistry, 1990 , vol. 55, # 21 p. 5662 - 5664
反应条件
1: 65 percent / trifluoroperacetic acid / CH2Cl2 / 1 h / 60 °C
2: 35 percent / 48 h / Ambient temperature
View Scheme
参考文献
Krapcho, A. Paul; Avery, Kenneth L.
Journal of Organic Chemistry, 1990 , vol. 55, # 21 p. 5662 - 5664
反应条件
1: H2SO4 / H2O / 1 h / Heating
2: 130 °C / 0.05 Torr
3: 89 percent / AlCl3, NaCl / 1.5 h / 220 °C
4: 78 percent / pyridine / 48 h / Ambient temperature
View Scheme
参考文献
Krapcho, A. Paul; Getahun, Zelleka; Avery, Kenneth J.
Synthetic Communications, 1990 , vol. 20, # 14 p. 2139 - 2146
反应条件
1: 58 percent / chromium trioxide, water / acetic acid / 12 h
2: 75 percent / BBr3 / CH2Cl2 / a.) from -78 deg C to -60 deg C, b.) RT, overnight
3: 78 percent / pyridine / 48 h / Ambient temperature
View Scheme
参考文献
Krapcho, A. Paul; Getahun, Zelleka; Avery, Kenneth J.
Synthetic Communications, 1990 , vol. 20, # 14 p. 2139 - 2146
反应条件
1: 96 percent / trifluoroacetic anhydride / CH2Cl2 / 6 h
2: 58 percent / chromium trioxide, water / acetic acid / 12 h
3: 75 percent / BBr3 / CH2Cl2 / a.) from -78 deg C to -60 deg C, b.) RT, overnight
4: 78 percent / pyridine / 48 h / Ambient temperature
View Scheme
参考文献
Krapcho, A. Paul; Getahun, Zelleka; Avery, Kenneth J.
Synthetic Communications, 1990 , vol. 20, # 14 p. 2139 - 2146
反应条件
1: 75 percent / BBr3 / CH2Cl2 / a.) from -78 deg C to -60 deg C, b.) RT, overnight
2: 78 percent / pyridine / 48 h / Ambient temperature
View Scheme
参考文献
Krapcho, A. Paul; Getahun, Zelleka; Avery, Kenneth J.
Synthetic Communications, 1990 , vol. 20, # 14 p. 2139 - 2146
