(2E,4E)-5-(4-甲氧基-2,3,6-三甲基苯基)-3-甲基-2,4-戊二烯醛合成路线 （共 22 条）
反应条件
1: 70 percent / NaOH / 1.) ethanol, water, 0 deg C, 4 h, 2.) reflux, 1 h 2: 76 percent / β,γ-lutidine, copper acetate / 2 h / Heating 3: 95 percent / I2 / diethyl ether; benzene / 8 h / 20 °C View Scheme
参考文献
Makin, S. M.; Mikerin, I. E.; Shavrygina, O. A.; Lanina, T. I.
Journal of Organic Chemistry USSR (English Translation), 1989 , vol. 25, # 4.2 p. 710 - 715
Zhurnal Organicheskoi Khimii, 1989 , vol. 25, # 4 p. 792 - 797
反应条件
manganese(IV) oxide; sodium carbonate in dichloromethane
T=25°C; 1 h;
参考文献
Magoulas, George E.; Bariamis, Stavros E.; Athanassopoulos, Constantinos M.; Haskopoulos, Anastasios; Dedes, Petros G.; Krokidis, Marios G.; Karamanos, Nikos K.; Kletsas, Dimitris; Papaioannou, Dionissios; Maroulis, George
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 2 p. 721 - 737
反应条件
triethylamine in diethyl ether
T=20°C; 24 h;
参考文献
Andriamialisoa, Zo; Valla, Alain; Cartier, Dominique; Labia, Roger
Helvetica Chimica Acta, 2002 , vol. 85, # 9 p. 2926 - 2929
反应条件
1: 90.7 percent / conc. H2SO4, 98percent aq. HNO3 / CHCl3 / 2 h / 0 °C
2: 75.5 percent / NaOH, H2 / Raney Ni / ethanol / 114000 Torr
3: 1.) 25percent aq, H2SO4, aq. NaNO2, 2.) 20percent aq. H2SO4 / 1.) 0 deg C, 1 h, 2.) reflux, 2 h
4: 98 percent / NaH / dimethylsulfoxide / 10 h
5: 72 percent / phosphorus oxychloride / 24 h / 70 °C
6: 87 percent / 10percent aq. NaOH / 6 h / Ambient temperature
7: diethyl ether / 1.) 20 deg C, 2 h, 2.) reflux, 1 h
8: 1.) phosphorus oxychloride / 2.) a) 0 deg C, 0.5 h, b) 70 deg C, 2 h
View Scheme
参考文献
Makin, S. M.; Mikerin, I. E.; Dobretsova, E. K.; Shavrygina, O. A.
Russian Journal of Organic Chemistry, 1993 , vol. 29, # 4 p. 572 - 575
Zhurnal Organicheskoi Khimii, 1993 , vol. 29, # 4 p. 682 - 686
反应条件
1: 75.5 percent / NaOH, H2 / Raney Ni / ethanol / 114000 Torr
2: 1.) 25percent aq, H2SO4, aq. NaNO2, 2.) 20percent aq. H2SO4 / 1.) 0 deg C, 1 h, 2.) reflux, 2 h
3: 98 percent / NaH / dimethylsulfoxide / 10 h
4: 72 percent / phosphorus oxychloride / 24 h / 70 °C
5: 87 percent / 10percent aq. NaOH / 6 h / Ambient temperature
6: diethyl ether / 1.) 20 deg C, 2 h, 2.) reflux, 1 h
7: 1.) phosphorus oxychloride / 2.) a) 0 deg C, 0.5 h, b) 70 deg C, 2 h
View Scheme
参考文献
Makin, S. M.; Mikerin, I. E.; Dobretsova, E. K.; Shavrygina, O. A.
Russian Journal of Organic Chemistry, 1993 , vol. 29, # 4 p. 572 - 575
Zhurnal Organicheskoi Khimii, 1993 , vol. 29, # 4 p. 682 - 686
反应条件
manganese(IV) oxide
Oxidation;
参考文献
Lewin; Black; Bos; Goehring; Nair; Whiting; Bouquin; Tetrault; Carroll
Pharmaceutical Research, 1995 , vol. 12, # 7 p. 983 - 992
反应条件
1: 95 percent / SnCl4
2: 100 percent
3: 83 percent
4: 99 percent / LiAlH4
5: 20 percent / MnO2
View Scheme
参考文献
Lewin; Black; Bos; Goehring; Nair; Whiting; Bouquin; Tetrault; Carroll
Pharmaceutical Research, 1995 , vol. 12, # 7 p. 983 - 992
反应条件
1: 72 percent / base
2: 95 percent / SnCl4
3: 100 percent
4: 83 percent
5: 99 percent / LiAlH4
6: 20 percent / MnO2
View Scheme
参考文献
Lewin; Black; Bos; Goehring; Nair; Whiting; Bouquin; Tetrault; Carroll
Pharmaceutical Research, 1995 , vol. 12, # 7 p. 983 - 992
反应条件
1: 100 percent
2: 83 percent
3: 99 percent / LiAlH4
4: 20 percent / MnO2
View Scheme
参考文献
Lewin; Black; Bos; Goehring; Nair; Whiting; Bouquin; Tetrault; Carroll
Pharmaceutical Research, 1995 , vol. 12, # 7 p. 983 - 992
反应条件
1.1: t-BuOK / cyclohexane / 1.5 h / Heating
1.2: 75 percent / cyclohexane / 1 h / 20 °C
2.1: 88 percent / HCO2H / cyclopentane / 1.5 h / 20 °C
3.1: Et3N / diethyl ether / 24 h / 20 °C
View Scheme
参考文献
Andriamialisoa, Zo; Valla, Alain; Cartier, Dominique; Labia, Roger
Helvetica Chimica Acta, 2002 , vol. 85, # 9 p. 2926 - 2929
