2-[(2’,6’-二氯苯基)氨基]-5-甲氧基苯基-N,N-二甲基乙酰胺合成路线 （共 4 条）
反应条件
1: 90 percent / BBr3 / CH2Cl2; 1,2-dichloro-ethane / 20 °C 2: 80 percent / aq. NaOH / ethanol / 36 h / 80 °C View Scheme
参考文献
Kenny, Jane R.; Maggs, James L.; Meng, Xiaoli; Sinnott, Deborah; Clarke, Stephen E.; Park, B. Kevin; Stachulski, Andrew V.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 11 p. 2816 - 2825
反应条件
copper(l) iodide; copper; potassium carbonate in toluene
Ullmann coupling; 24 h; Heating;
参考文献
Kenny, Jane R.; Maggs, James L.; Meng, Xiaoli; Sinnott, Deborah; Clarke, Stephen E.; Park, B. Kevin; Stachulski, Andrew V.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 11 p. 2816 - 2825
反应条件
1: 80 percent / N-iodosuccinimide / acetonitrile / 12 h / Heating
2: 91 percent / K2CO3; CuI; Cu / toluene / 24 h / Heating
View Scheme
参考文献
Kenny, Jane R.; Maggs, James L.; Meng, Xiaoli; Sinnott, Deborah; Clarke, Stephen E.; Park, B. Kevin; Stachulski, Andrew V.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 11 p. 2816 - 2825
反应条件
boron tribromide in dichloromethane; 1,2-dichloro-ethane
T=20°C;
参考文献
Kenny, Jane R.; Maggs, James L.; Meng, Xiaoli; Sinnott, Deborah; Clarke, Stephen E.; Park, B. Kevin; Stachulski, Andrew V.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 11 p. 2816 - 2825
