2-[2-(2',6'-二氯-4'-氢x苯基氨基)苯基]-N,N-二甲基乙酰胺合成路线 （共 10 条）
反应条件
copper(l) chloride; sodium hydroxide in ethanol T=90°C; 24 h; Inert atmosphere;
参考文献
Kim, Sang-Hyun; Kwon, Jung-Hwan; Yoon, Sung-Hwa
Bulletin of the Korean Chemical Society, 2010 , vol. 31, # 10 p. 3007 - 3009
反应条件
boron tribromide in dichloromethane; 1,2-dichloro-ethane
T=20°C; 1 h;
参考文献
Kenny, Jane R.; Maggs, James L.; Meng, Xiaoli; Sinnott, Deborah; Clarke, Stephen E.; Park, B. Kevin; Stachulski, Andrew V.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 11 p. 2816 - 2825
反应条件
boron tribromide in dichloromethane
T=0°C; 1 h; Inert atmosphere;
参考文献
Kim, Sang-Hyun; Kwon, Jung-Hwan; Yoon, Sung-Hwa
Bulletin of the Korean Chemical Society, 2010 , vol. 31, # 10 p. 3007 - 3009
反应条件
1: 45 percent / HCl (gas) / diethyl ether / 1 h / -10 - 0 °C
2: 82 percent / K2CO3; CuI; Cu / toluene / 48 h / Heating
3: 81 percent / BBr3 / CH2Cl2; 1,2-dichloro-ethane / 1 h / 20 °C
View Scheme
参考文献
Kenny, Jane R.; Maggs, James L.; Meng, Xiaoli; Sinnott, Deborah; Clarke, Stephen E.; Park, B. Kevin; Stachulski, Andrew V.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 11 p. 2816 - 2825
反应条件
1: 0.46 g / CH2Cl2; H2O / 1 h / 0 °C
2: 82 percent / K2CO3; CuI; Cu / toluene / 48 h / Heating
3: 81 percent / BBr3 / CH2Cl2; 1,2-dichloro-ethane / 1 h / 20 °C
View Scheme
参考文献
Kenny, Jane R.; Maggs, James L.; Meng, Xiaoli; Sinnott, Deborah; Clarke, Stephen E.; Park, B. Kevin; Stachulski, Andrew V.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 11 p. 2816 - 2825
反应条件
1: oxalyl chloride; DMF / CH2Cl2 / 2 h / 20 °C
2: 0.46 g / CH2Cl2; H2O / 1 h / 0 °C
3: 82 percent / K2CO3; CuI; Cu / toluene / 48 h / Heating
4: 81 percent / BBr3 / CH2Cl2; 1,2-dichloro-ethane / 1 h / 20 °C
View Scheme
参考文献
Kenny, Jane R.; Maggs, James L.; Meng, Xiaoli; Sinnott, Deborah; Clarke, Stephen E.; Park, B. Kevin; Stachulski, Andrew V.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 11 p. 2816 - 2825
反应条件
1: 82 percent / K2CO3; CuI; Cu / toluene / 48 h / Heating
2: 81 percent / BBr3 / CH2Cl2; 1,2-dichloro-ethane / 1 h / 20 °C
View Scheme
参考文献
Kenny, Jane R.; Maggs, James L.; Meng, Xiaoli; Sinnott, Deborah; Clarke, Stephen E.; Park, B. Kevin; Stachulski, Andrew V.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 11 p. 2816 - 2825
反应条件
1: 82 percent / K2CO3; CuI; Cu / toluene / 48 h / Heating
2: 81 percent / BBr3 / CH2Cl2; 1,2-dichloro-ethane / 1 h / 20 °C
View Scheme
参考文献
Kenny, Jane R.; Maggs, James L.; Meng, Xiaoli; Sinnott, Deborah; Clarke, Stephen E.; Park, B. Kevin; Stachulski, Andrew V.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 11 p. 2816 - 2825
反应条件
1: copper(l) iodide; potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 20 h / 150 °C / Inert atmosphere
2: boron tribromide / dichloromethane / 1 h / 0 °C / Inert atmosphere
View Scheme
参考文献
Kim, Sang-Hyun; Kwon, Jung-Hwan; Yoon, Sung-Hwa
Bulletin of the Korean Chemical Society, 2010 , vol. 31, # 10 p. 3007 - 3009
反应条件
1: sulfuric acid; sodium nitrite / water / 1 h / 0 °C
2: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C / Inert atmosphere
3: copper(l) iodide; potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 20 h / 150 °C / Inert atmosphere
4: boron tribromide / dichloromethane / 1 h / 0 °C / Inert atmosphere
View Scheme
参考文献
Kim, Sang-Hyun; Kwon, Jung-Hwan; Yoon, Sung-Hwa
Bulletin of the Korean Chemical Society, 2010 , vol. 31, # 10 p. 3007 - 3009
