2-氨基-3-硝基-4-氯吡啶合成路线 （共 12 条）
反应条件
sulfuric acid; nitric acid T=0 - 4°C; 120 h;
参考文献
Chen, Danqi; Wang, Ying; Ma, Yuchi; Xiong, Bing; Ai, Jing; Chen, Yi; Geng, Meiyu; Shen, Jingkang
ChemMedChem, 2012 , vol. 7, # 6 p. 1057 - 1070
反应条件
1: With sulfuric acid; nitric acid T=0 - 5°C; 2: With sulfuric acid T=0 - 20°C; 3 h;
参考文献
Tetrahedron Letters, , vol. 53, # 42 p. 5597 - 5601
反应条件
sulfuric acid; nitric acid T=4 - 20°C; 3 h;
参考文献
WO2007/7919 A2, ;
Page/Page column 37-38 ;
WO 2007/007919 A2
反应条件
potassium permanganate; ammonia T=-33°C; 5 h;
参考文献
Liebigs Annalen der Chemie, , # 9 p. 875 - 878
反应条件
sulfuric acid T=0 - 20°C; other substituted 2- and 4-amino-pyridines; other temp.; Product distribution;
参考文献
Australian Journal of Chemistry, , vol. 35, # 10 p. 2025 - 2034
反应条件
N-bromosuccinmide in acetonitrile T=80°C; 1 h;
参考文献
CANCER RESEARCH TECHNOLOGY LIMITED; BLAGG, Julian; BAVETSIAS, Vassilios; MOORE, Andrew S.; LINARDOPOULOS, Spyridon
Patent: WO2013/190320 A1, 2013 ;
Location in patent: Paragraph 00119 ;
反应条件
1: T=60°C; 16 h; 2: With hydrogenchloride in water pH=6;
参考文献
H. LUNDBECK A/S; JØRGENSEN, Morten; BRUUN, Anne Techau; RASMUSSEN, Lars Kyhn
Patent: WO2013/34761 A1, 2013 ;
Location in patent: Page/Page column 19 ;
反应条件
sodium 2 h; Heating;
参考文献
Barraclough; Black; Cambridge; Collard; Firmin; Gerskowitch; Glen; Giles; Hill; Hull; Iyer; King; Kneen; Lindon; Nobbs; Randall; Shah; Smith; Vine; et al.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 8 p. 2231 - 2239
参考文献
IRM LLC
Patent: WO2008/144253 A1, 2008 ;
Location in patent: Page/Page column 60-61 ;
WO 2008/144253 A1
反应条件
hydrogenchloride; water; sodium nitrite T=0 - 70°C;
参考文献
INDOCO REMEDIES LIMITED; VYAS, Ketan Dhansukhlal; NAIR, Ranjeet; JADHAV, Vidyadhar Kashinath; BHATT, Nikunj; DESHMUKH, Sandip Kacharu; PANSARE, Prakash Popat; SINGH, Rajesh Kumar; PANANDIKAR, Aditi Milind
Patent: WO2010/89773 A2, 2010 ;
Location in patent: Page/Page column 15 ;
