4,6-二羟基烟酸乙酯合成路线

参考文献

Montoir, David; Tonnerre, Alain; Duflos, Muriel; Bazin, Marc-Antoine
European Journal of Organic Chemistry, 2014 , vol. 2014, # 7 p. 1487 - 1495

105-50-01,3-丙酮二羧酸二乙酯+

149-73-5原甲酸三甲酯

6975-44-64,6-二羟基烟酸乙酯

参考文献

BIOTA EUROPE LTD; TYNDALL, Edward Malcolm; CZAPLEWSKI, Lloyd George; FISHWICK, Colin William Gordon; YULE, Ian Andrew; MITCHELL, Jeffrey Peter; ANDERSON, Kelly Helen; PITT, Gary Robert William
Patent: WO2013/91011 A1, 2013 ;
Location in patent: Page/Page column 66; 67 ;

108-24-7乙酸酐+

105-50-01,3-丙酮二羧酸二乙酯

6975-44-64,6-二羟基烟酸乙酯

参考文献

Deciphera Pharmaceuticals, LLC; Flynn, Daniel L.; Kaufman, Michael D.; Petillo, Peter A.
Patent: US8461179 B1, 2013 ;
Location in patent: Page/Page column 66 ;

参考文献

FLYNN, Daniel L.; KAUFMAN, Michael D.
Patent: WO2013/184119 A1, 2013 ;
Location in patent: Paragraph 0203 ;

参考文献

Gazzetta Chimica Italiana, , vol. 28 I, p. 482,484, 487
Chemische Berichte, , vol. 31, p. 1683,1684, 1685

6975-44-64,6-二羟基烟酸乙酯

107836-75-94,6-二氯烟酰氯

参考文献

Platts, Michelle Y.; Barber, Christopher G.; Chiva, Jean-Yves; Eastwood, Rachel L.; Fenwick, David R.; Paradowski, Kerry A.; Blakemore, David C.
Tetrahedron Letters, 2011 , vol. 52, # 4 p. 512 - 514

6975-44-64,6-二羟基烟酸乙酯

405230-82-22,5-二氯-4-氨基吡啶

参考文献

den Hertog et al.
Recueil des Travaux Chimiques des Pays-Bas, 1950 , vol. 69, p. 673,690

6975-44-64,6-二羟基烟酸乙酯

40296-46-64,6-二氯烟酸乙酯

参考文献

Montoir, David; Tonnerre, Alain; Duflos, Muriel; Bazin, Marc-Antoine
European Journal of Organic Chemistry, 2014 , vol. 2014, # 7 p. 1487 - 1495

6975-44-64,6-二羟基烟酸乙酯

143834-60-02,4-二羟基-5-羟甲基吡啶

参考文献

Tetrahedron, , vol. 48, # 30 p. 6225 - 6230

6975-44-64,6-二羟基烟酸乙酯

449811-29-46-氯-4-(甲基氨基)烟醛

参考文献

WO2011/97526 A1, ;
WO 2011/097526 A1