3-羟基-2,2-二甲基丁酸乙酯合成路线 （共 7 条）
反应条件
ammonium chloride; diisopropylamine in tetrahydrofuran; n-heptane; ethylbenzene
参考文献
NEREUS PHARMACEUTICALS, INC.; YAMAZAKI, Yuri; HAYASHI, Yoshio
Patent: WO2011/84962 A1, 2011 ;
Location in patent: Page/Page column 29-30 ;
反应条件
sodium tetrahydroborate in methanol
参考文献
Kim, Hyoung Rae; Shin, Seung Il; Park, Hyun Ju; Jeon, Dong Ju; Ryu, Eung K.
Synlett, 1998 , # 7 p. 789 - 791
反应条件
InI3; dimethylphenylsilane in dichloromethane T=20°C; Mukaiyama reaction; 2 h; chemoselective reaction;
参考文献
Inamoto, Yoshihiro; Nishimoto, Yoshihiro; Yasuda, Makoto; Baba, Akio
Organic Letters, 2012 , vol. 14, # 4 p. 1168 - 1171
反应条件
InI3; phenyl silane in dichloromethane T=20°C; 1 h;
参考文献
Chemistry Letters, , vol. 42, # 12 p. 1551 - 1553
反应条件
1: 78 percent / P2O5 / benzene 2: 84 percent / LiOH, H2O / ethanol / Ambient temperature View Scheme
参考文献
Synlett, , # 7 p. 789 - 791
反应条件
1.1: pyridine / 60 h / 0 - 20 °C
2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / 3.5 h / 140 - 160 °C
3.1: sodium hydroxide; ethanol
4.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 17 h / 0 - 20 °C
5.1: n-butyllithium / tetrahydrofuran; hexanes / -70 - -10 °C / Inert atmosphere
5.2: 3 h / -60 - 0 °C
View Scheme
参考文献
NEREUS PHARMACEUTICALS, INC.; YAMAZAKI, Yuri; HAYASHI, Yoshio
Patent: WO2011/84962 A1, 2011 ;
反应条件
1: 78 percent / P2O5 / benzene
2: 84 percent / LiOH, H2O / ethanol / Ambient temperature
3: SOCl2
View Scheme
参考文献
NEREUS PHARMACEUTICALS, INC.; YAMAZAKI, Yuri; HAYASHI, Yoshio
Patent: WO2011/84962 A1, 2011 ;
