3-(2-氨基-4-氯苯基)-4H-[1,2,4]噁二唑-5-酮合成路线 （共 3 条）
反应条件
sodium ethanolate
18 h; Heating / reflux;
参考文献
NEUROSEARCH A/S
Patent: WO2004/46090 A2, 2004 ;
Location in patent: Page 20-21 ;
WO 2004/046090 A2
反应条件
sodium ethanolate in ethanol
18 h; Heating;
参考文献
Valgeirsson, Jon; Nielsen, Elsebet .; Peters, Dan; Mathiesen, Claus; Kristensen, Anders S.; Madsen, Ulf
Journal of Medicinal Chemistry, 2004 , vol. 47, # 27 p. 6948 - 6957
反应条件
1: 86 percent / aq. NH2OH*HCl; NaHCO3 / ethanol / 8 h / Heating
2: 80 percent / EtONa / ethanol / 18 h / Heating
View Scheme
参考文献
Valgeirsson, Jon; Nielsen, Elsebet .; Peters, Dan; Mathiesen, Claus; Kristensen, Anders S.; Madsen, Ulf
Journal of Medicinal Chemistry, 2004 , vol. 47, # 27 p. 6948 - 6957
