4,5-二甲基-2-硝基苯胺合成路线 （共 37 条）
反应条件
hydrogenchloride; tin(ll) chloride beim anschliessenden Behandeln des Reaktionsprudukts mit Alloxan in H2O;
参考文献
Sahashi et al.
Proceedings of the Japan Academy, 1945 , vol. 21, p. 44,51, 55
反应条件
1: arsenic (V)-oxide; aqueous sulfuric acid / 140 °C 2: SnCl2+2 H2O; ethanol View Scheme
参考文献
Case
Journal of the American Chemical Society, 1948 , vol. 70, p. 3994
反应条件
1: hydrogenchloride; sodium nitrite / water / 0.17 h / |Cooling with ice 2: borane dimethyl sulfide complex / tetrahydrofuran / 2.5 h / 50 - 60 °C / |Inert atmosphere 3: sodium acetate / acetic acid / 2 h / |Inert atmosphere; |Reflux View Scheme
参考文献
Yu, Li-Fang; Li, Yuan-Yuan; Su, Ming-Bo; Zhang, Mei; Zhang, Wei; Zhang, Li-Na; Pang, Tao; Zhang, Run-Tao; Liu, Bing; Li, Jing-Ya; Li, Jia; Nan, Fa-Jun
ACS Medicinal Chemistry Letters, 2013 , vol. 4, # 5 p. 475 - 480
反应条件
acetic acid Clauson-Kaas reaction; 1 h; Heating;
参考文献
Campiani, Giuseppe; Morelli, Elena; Gemma, Sandra; Nacci, Vito; Butini, Stefania; Hamon, Michel; Novellino, Ettore; Greco, Giovanni; Cagnotto, Alfredo; Goegan, Mara; Cervo, Luigi; Valle, Fabio Dalla; Fracasso, Claudia; Caccia, Silvio; Mennini, Tiziana
Journal of Medicinal Chemistry, 1999 , vol. 42, # 21 p. 4362 - 4379
参考文献
Clark et al.
Brit.J.Pharmacol., 1958 , vol. 13, p. 424
反应条件
1: (i) NaNO2, aq. HCl, (ii) /BRN= 3587243/, CuCN, aq. Na2CO3, toluene
2: aq. H2SO4
3: H2 / Pd-C / acetic acid
View Scheme
参考文献
Braendstroem,A.; Carlsson,A.I.
Acta Chemica Scandinavica (1947-1973), 1967 , vol. 21, p. 983 - 992
反应条件
1: (i) H2SO4, NaNO2, (ii) KI
2: Cu / 150 - 200 °C
View Scheme
参考文献
Mazere,I.V. et al.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1972 , vol. 8, p. 1446 - 1448
Khimiya Geterotsiklicheskikh Soedinenii, 1972 , vol. 8, # 12 p. 1597 - 1599
反应条件
1: acetic acid
2: iron; acetic acid
3: aqueous acetic acid; NaNO2
View Scheme
参考文献
Benson et al.
Journal of the American Chemical Society, 1952 , vol. 74, p. 4917,4919
反应条件
FeCl3·6H2O; sulfur in neat (no solvent)
T=120°C; 24 h; Inert atmosphere;
参考文献
Nguyen, Thanh Binh; Retailleau, Pascal; Al-Mourabit, Ali
Organic Letters, 2013 , vol. 15, # 20 p. 5238 - 5241
反应条件
hydrogenchloride; sodium tetrafluoroborate; sodium nitrite in water
T=0 - 25°C; 1 h; Heating;
参考文献
MERCK PATENT GmbH
Patent: WO2006/125511 A1, 2006 ;
Location in patent: Page/Page column 45 ;
