7-硝基吲哚-2-甲酸乙酯合成路线 （共 9 条）
反应条件
polyphosphoric acid T=70 - 80°C; 12 h;
参考文献
Purzer Pharmaceutical Co., Ltd.
Patent: EP2366687 A2, 2011 ;
Location in patent: Page/Page column 8-10 ;
反应条件
PPA T=50 - 60°C; 4 h;
参考文献
Narayana; Ashalatha; Vijaya Raj; Fernandes; Sarojini
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 15 p. 4638 - 4644
参考文献
Murakami; Watanabe; Yokoyama; Naomachi; Iwase; Morihata; Okuyama; Kamakura; Takahashi; Atoda; Tojo; Morita; Ishii
Chemical and Pharmaceutical Bulletin, 1993 , vol. 41, # 11 p. 1910 - 1919
反应条件
Bi(NO3)3; PPA in methanol 2.5 h; Reflux;
参考文献
Sudhakara; Jayadevappa; Mahadevan; Hulikal, Vijaykumar
Synthetic Communications, 2009 , vol. 39, # 14 p. 2506 - 2515
反应条件
1: 1.) NaNO2, aq. HCl, 2.) 50percent KOH/EtOH / 1.) 0-4 deg C, 2.) 0-7 deg C, 1 h 2: phosphoric acid / ethanol / 0.33 h / Heating 3: 78 percent / PPA / 0.5 h / 120 °C View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 41, # 11 p. 1910 - 1919
反应条件
1: ethanol / 0.17 h / 20 °C 2: PPA / 7 h / 50 - 80 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 22, # 6 p. 1850 - 1862
反应条件
1: With water; potassium hydroxide in ethanol T=40°C; 2: With hydrogenchloride in ethanol; water
参考文献
Purzer Pharmaceutical Co., Ltd.
Patent: EP2366687 A2, 2011 ;
Location in patent: Page/Page column 8; 10 ;
反应条件
1: aq.-ethanolic KOH 2: copper (II)-oxide; quinoline / 205 °C View Scheme
参考文献
Purzer Pharmaceutical Co., Ltd.
Patent: EP2366687 A2, 2011 ;
反应条件
1: potassium hydroxide; water / ethanol / 40 °C 2: copper(II) oxide / quinoline / 2 h / 194 °C 3: hydrogen / palladium 10 on activated carbon / methanol / 1 h View Scheme
