1: 3-chloro-4-hydroxy-aniline With benzaldehyde in N,N-dimethyl-formamide 0.166667 h; 2: 2-chloromethyl-pyridine hydrochloride With potassium carbonate in N,N-dimethyl-formamide T=50°C; 24 h; 3: With hydrogenchloride; sodium hydroxide; water more than 3 stages;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2006/64196 A1, 2006 ;
Location in patent: Page/Page column 97 ;
WO 2006/064196 A1