(S)-2-(氨甲基)吡咯烷合成路线 （共 9 条）
反应条件
in tetrahydrofuran; water
参考文献
Chugai Seiyaku Kabushiki Kaisha
Patent: US4822892 A1, 1989 ;
反应条件
1: 1) HCl(g), 2) Na2CO3 / 1) 3h, 2) benzene, 9h, reflux 2: 51 percent / NH3(g) / methanol / 0 °C 3: 41 percent / LiAlH4 / tetrahydrofuran / 8 h / Heating 4: 28 percent / HCOOH / 10percent Pd-C / methanol / 0.33 h View Scheme
参考文献
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), , vol. 40, # 1.1 p. 110 - 118
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, , # 1 p. 126 - 134
反应条件
formic acid; palladium on activated charcoal in methanol 0.333333 h;
参考文献
Belokon', Yu. N.; Maleev, V. I.; Videnskaya, S. O.; Saporovskaya, M. B.; Tsyryapkin, V. A.; Belikov, V. M.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1991 , vol. 40, # 1.1 p. 110 - 118
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1991 , # 1 p. 126 - 134
反应条件
1: 88.4 percent / hydrogen / 10percent palladium on carbon / methanol / 9 h / Ambient temperature 2: 36.8 percent / lithium aluminum hydride / tetrahydrofuran / 33 h / Heating View Scheme
参考文献
Journal of Pharmaceutical Sciences, , vol. 80, # 9 p. 837 - 842
反应条件
1: 1.) triethylamine, isobutyl chloroformate, 2.) ammonia / 1.) chloroform, 0 deg C, 2 h, 2.) chloroform, RT, overnight 2: 88.4 percent / hydrogen / 10percent palladium on carbon / methanol / 9 h / Ambient temperature 3: 36.8 percent / lithium aluminum hydride / tetrahydrofuran / 33 h / Heating View Scheme
参考文献
Journal of Pharmaceutical Sciences, , vol. 80, # 9 p. 837 - 842
反应条件
lithium aluminium tetrahydride in tetrahydrofuran; diethyl ether 27 h; Heating;
参考文献
Journal of Medicinal Chemistry, , vol. 25, # 11 p. 1280 - 1286
反应条件
1: 51 percent / NH3(g) / methanol / 0 °C 2: 41 percent / LiAlH4 / tetrahydrofuran / 8 h / Heating 3: 28 percent / HCOOH / 10percent Pd-C / methanol / 0.33 h View Scheme
参考文献
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), , vol. 40, # 1.1 p. 110 - 118
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, , # 1 p. 126 - 134
反应条件
1: 41 percent / LiAlH4 / tetrahydrofuran / 8 h / Heating 2: 28 percent / HCOOH / 10percent Pd-C / methanol / 0.33 h View Scheme
参考文献
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), , vol. 40, # 1.1 p. 110 - 118
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, , # 1 p. 126 - 134
反应条件
1: methanol; NH3 2: THF; LiAlH4 View Scheme
参考文献
Helvetica Chimica Acta, , vol. 38, p. 2036
