5-甲氧基-4(3H)-嘧啶酮合成路线 （共 5 条）
反应条件
1: 74 percent / POCl3, DIPEA 2: Et3N / CH2Cl2 / 10 h / 60 °C 3: NaPH / CH2Cl2; butan-1-ol; diethyl ether / 10 h / 90 °C View Scheme
参考文献
Brodfuehrer; Chen; Sattelberg T.R.; Smith; Reddy; Stark; Quinlan; Reid
Journal of Organic Chemistry, 1997 , vol. 62, # 26 p. 9192 - 9202
参考文献
McOmie; Chesterfield
Chemistry and Industry (London, United Kingdom), 1956 , p. 1453
反应条件
1: With trichlorophosphate T=0°C; Inert atmosphereReflux; 2: With potassium carbonate in water pH=7;
参考文献
Myllymaeki, Mikko J.; Kaesnaenen, Heikki; Kataja, Antti O.; Lahtela-Kakkonen, Maija; Saario, Susanna M.; Poso, Antti; Koskinen, Ari M.P.
European Journal of Medicinal Chemistry, 2009 , vol. 44, # 10 p. 4179 - 4191
反应条件
sodium hydroxide; N-ethyl-N,N-diisopropylamine; trichlorophosphate in toluene
参考文献
Bristol-Myers Squibb Company
Patent: US5550239 A1, 1996 ;
反应条件
trichlorophosphate
0.5 h; Heating;
参考文献
Yamanaka, Hiroshi; Sakamoto, Takao; Nishimura, Sumiko; Sagi, Mataichi
Chemical and Pharmaceutical Bulletin, 1987 , vol. 35, # 8 p. 3119 - 3126
