2-氨基-4-甲基吡啶合成路线 （共 193 条）
反应条件
hydrogen bromide; dihydrogen peroxide T=70°C; 1 h; Product distribution;
参考文献
Dunn, A. D.; Currie, A.; Hayes, L. E.
Journal fuer Praktische Chemie (Leipzig), 1989 , vol. 331, # 3 p. 369 - 374
反应条件
1: ethanol; bromine 2: concentrated H2SO4; concentrated HNO3 3: SnCl2; aqueous HCl View Scheme
参考文献
Wu, Runzhi; Smidansky, Eric D.; Oh, Hyung Suk; Takhampunya, Ratree; Padmanabhan, Radhakrishnan; Cameron, Craig E.; Peterson, Blake R.
Journal of Medicinal Chemistry, 2010 , vol. 53, # 22 p. 7958 - 7966
反应条件
1: sulfuric acid; nitric acid 2: tetrafluoroboric acid; EtO-NO View Scheme
参考文献
Timperley, Christopher M.; Banks, R. Eric; Young, Ian M.; Haszeldine, Robert N.
Journal of Fluorine Chemistry, 2011 , vol. 132, # 8 p. 541 - 547
反应条件
1: sulfuric acid; nitric acid 2: tetrafluoroboric acid; EtO-NO 3: iodine; potassium acetate / acetic anhydride 4: ozone View Scheme
参考文献
Timperley, Christopher M.; Banks, R. Eric; Young, Ian M.; Haszeldine, Robert N.
Journal of Fluorine Chemistry, 2011 , vol. 132, # 8 p. 541 - 547
反应条件
sodium nitrite in tetrafluoroboric acid; water
参考文献
Research Foundation Of State University Of New York
Patent: US5583148 A1, 1996 ;
反应条件
tetrafluoroboric acid; sodium nitrite 0 deg C to rt;
参考文献
Ashimori; Ono; Uchida; Ohtaki; Fukaya; Watanabe; Yokoyama
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 9 p. 2446 - 2458
反应条件
formaldehyd; sodium cyanoborohydride in water; acetonitrile T=0 - 20°C; 168 h;
参考文献
SB PHARMCO PUERTO RICO INC.; NEUROCRINE BIOSCIENCES INC.
Patent: WO2006/44958 A1, 2006 ;
Location in patent: Page/Page column 38-39 ;
WO 2006/044958 A1
反应条件
sodium hydride in N,N-dimethyl-formamide T=0°C; Inert atmosphere;
参考文献
Mita, Tsuyoshi; Michigami, Kenichi; Sato, Yoshihiro
Chemistry - An Asian Journal, 2013 , vol. 8, # 12 p. 2970 - 2973
反应条件
sodium cyanoborohydride; acetic acid in water; acetonitrile T=20°C; 168 h;
参考文献
Chen, Chen; Wilcoxen, Keith M.; Huang, Charles Q.; Xie, Yun-Feng; McCarthy, James R.; Webb, Thomas R.; Zhu, Yun-Fei; Saunders, John; Liu, Xin-Jun; Chen, Ta-Kung; Bozigian, Haig; Grigoriadis, Dimitri E.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 19 p. 4787 - 4798
反应条件
1: acetone / 20 °C 2: bis(trichloromethyl) carbonate / chloroform / 4.5 h / 0 - 20 °C View Scheme
参考文献
Liu, Pengfei; Li, Chunyan; Zhang, Jingwei; Xu, Xiaoyong
Synthetic Communications, 2013 , vol. 43, # 24 p. 3342 - 3351
