2-氨基-4-甲基吡啶合成路线 （共 193 条）
反应条件
bromine in acetic acid T=20°C; 1 h;
参考文献
Lindstroem, Stefan; Ahmad, Tania; Grivas, Spiros
Heterocycles, 1994 , vol. 38, # 3 p. 529 - 540
反应条件
hydrogen bromide; dihydrogen peroxide T=70°C; 1 h; Product distribution;
参考文献
Journal fuer Praktische Chemie (Leipzig), , vol. 331, # 3 p. 369 - 374
反应条件
sulfuric acid; iodine; acetic acid; periodic acid in water T=80°C; 6 h;
参考文献
ZOETIS LLC; MENON, Sanjay; SHEEHAN, Susan M.K.; VAILLIANCOURT, Valerie A.
Patent: WO2014/39484 A1, 2014 ;
Location in patent: Page/Page column 60 ;
反应条件
N-iodo-succinimide; acetic acid in benzene T=20°C; 72 h; regioselective reaction;
参考文献
Synlett, , # 2 p. 208 - 214
反应条件
1: With sulfuric acid; nitric acid 2: With hydrogenchloride; sodium nitrite Further stages;
参考文献
Timperley, Christopher M.; Banks, R. Eric; Young, Ian M.; Haszeldine, Robert N.
Journal of Fluorine Chemistry, 2011 , vol. 132, # 8 p. 541 - 547
反应条件
1: diazonium reaction View Scheme
参考文献
Potts, Kevin T.
Bulletin des Societes Chimiques Belges, 1990 , vol. 99, # 9 p. 741 - 768
反应条件
1: bromine 2: nitric acid; sulfuric acid 3: chloro-trimethyl-silane; sodium nitrite 5: sodium methylate; ammonium chloride / copper(l) iodide / tetrahydrofuran 6: hydrogen / 1 wt Pd/C / ethyl acetate View Scheme
反应条件
1.1: nitric acid; sulfuric acid / 24 h / 0 - 50 °C 1.2: pH 7 / Cooling with ice 2.1: water; sodium nitrite; sulfuric acid / 2 h / 0 - 20 °C 3.1: trichlorophosphate / 5 h / Reflux 4.1: sodium dichromate; sulfuric acid / 6 h / 60 °C View Scheme
参考文献
Beijing Yiling Bioengineering Co., Ltd.
Patent: EP2366691 A1, 2011 ;
反应条件
1.1: 1,3-dibromo-5,5-dimethyl-hydantoin / dichloromethane / 0.5 h / -45 °C 1.2: -45 - 22 °C 2.1: sulfuric acid; nitric acid / -10 - 22 °C 3.1: sulfuric acid / 2 h / 22 °C 3.2: 22 °C 4.1: hydrogenchloride; tin(ll) chloride / water / 0 - 100 °C 5.1: 1 h / Erfllectrochemical reaction View Scheme
参考文献
Wu, Runzhi; Smidansky, Eric D.; Oh, Hyung Suk; Takhampunya, Ratree; Padmanabhan, Radhakrishnan; Cameron, Craig E.; Peterson, Blake R.
Journal of Medicinal Chemistry, 2010 , vol. 53, # 22 p. 7958 - 7966
反应条件
1: 51 percent / NaNO2, HBF4 / 0 deg C to rt 2: 26 percent / KMnO4 / H2O / Heating View Scheme
参考文献
Roe et al.
Journal of the American Chemical Society, 1949 , vol. 71, p. 4152
