3-溴-4,5-二甲氧基苯甲醛合成路线 （共 42 条）
反应条件
potassium carbonate; copper(II) oxide in pyridine T=150°C; 17 h;
参考文献
Archiv der Pharmazie, , vol. 316, # 7 p. 624 - 629
反应条件
potassium carbonate; copper(II) oxide in pyridine T=150°C; 26 h;
参考文献
Archiv der Pharmazie, , vol. 316, # 7 p. 624 - 629
反应条件
1: tetrahydrofuran / 0.25 h / -75 - -50 °C 2: n-BuLi / 0.58 h / -75 °C 3: nitrobenzene / 4 h / -75 °C 4: H3O(1+) / 0.25 h View Scheme
参考文献
Sinhababu, Achintya K.; Borchardt, Ronald T.
Journal of Organic Chemistry, 1983 , vol. 48, # 12 p. 1941 - 1944
反应条件
copper dichloride in N,N-dimethyl-formamide T=120°C;
参考文献
Puri, S. C.; Anand, S. M.; Atal, C. K.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1985 , vol. 24, p. 294 - 295
反应条件
1: 39 percent / dimethylamine / 4 h / Heating 2: 74 percent / BBr3 / CH2Cl2 / 20 °C View Scheme
参考文献
Baeckstroem, Reijo; Honkanen, Erkki; Pippuri, Aino; Kairisalo, Pekka; Pystynen, Jarmo; et al.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 4 p. 841 - 846
反应条件
formic acid; hydroxylamine hydrochloride; sodium formate T=50 - 120°C; 55 h;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH
Patent: US2012/28939 A1, 2012 ;
Location in patent: Page/Page column 21 ;
反应条件
potassium permanganate
参考文献
Pschorr
Justus Liebigs Annalen der Chemie, 1912 , vol. 391, p. 44
参考文献
Dakin
American Chemical Journal, 1909 , vol. 42, p. 495
反应条件
1.1: mCPBA / CH2Cl2 / 11 h / Heating 1.2: 81 percent / Et3N / methanol / 2 h / 20 °C 2.1: 74 percent / DBU / 72 h / 75 °C 3.1: 80 percent / AlCl3 / nitromethane; H2O / 0.5 h / 60 °C 4.1: 84 percent / TsOH / toluene; various solvent(s) / 11 h / 80 °C 5.1: n-BuLi / tetrahydrofuran / 1 h / -78 °C 6.1: HCl / methanol / 2 h / 20 °C 7.1: 65 percent / I2 / dimethylsulfoxide / 5 h / 110 °C 8.1: 88 percent / Pd(OAc)2 / triethylamine; acetonitrile / 7.5 h / 50 °C 9.1: 40 percent / 2,6-di-t-butyl-4-methylphenol; air / toluene / 24 h / 200 °C 10.1: 74 percent / AlCl3 / toluene / 2 h / 110 °C View Scheme
参考文献
Chemistry Letters, , vol. 36, # 1 p. 10 - 11
反应条件
1.1: toluene / Heating 2.1: dimethylamine-boran complex; acetic acid 3.1: LDA / tetrahydrofuran / -78 - 20 °C 3.2: 17 percent / manganese dioxide View Scheme
参考文献
Nakanishi; Suzuki
Organic letters, 1999 , vol. 1, # 7 p. 985 - 988
