5-氨基-2-溴苯甲酸甲酯合成路线 （共 7 条）
反应条件
iron; ammonium chloride in methanol; water T=70°C; 1.75 h;
参考文献
Chin, Elbert; Li, Jim; Lui, Albert Sui-Ting; Talamas, Francisco Xavier
Patent: US2010/297073 A1, 2010 ;
Location in patent: Page/Page column 20 ;
反应条件
1: With acetyl chloride T=0 - 55°C; 3.5 h; 2: With sodium hydrogencarbonate in water pH=8;
参考文献
WO2007/99200 A1, ;
Page/Page column 9-10 ;
WO 2007/099200 A1
反应条件
hydrogenchloride; potassium hydrogencarbonate in methanol
参考文献
US2002/123484 A1, ;
US 20020123484 A1
反应条件
N-bromosuccinmide in dimethyl sulfoxide T=20°C;
参考文献
Synthesis, , # 8 art. no. P12608SS, p. 1305 - 1308
反应条件
N-bromosuccinmide in DCE T=20°C;
参考文献
Synthesis, , # 8 art. no. P12608SS, p. 1305 - 1308
反应条件
1: triethylamine / dichloromethane / 2.5 h / 0 °C / Cooling with ice 2: nitric acid; sulfuric acid / 1.5 h / 0 °C View Scheme
参考文献
Santen Pharmaceutical Co., Ltd
Patent: EP2327699 A1, 2011 ;
反应条件
1: With sulfuric acid; sodium nitrite in water
T=0°C; 0.25 h;
2: With copper; potassium iodide in water
8 h; Reflux;
参考文献
Carlson, Erik J.; Riel, Asia Marie S.; Dahl, Bart J.
Tetrahedron Letters, 2012 , vol. 53, # 46 p. 6245 - 6249,5
