5-溴异吲哚-1,3-二酮合成路线 （共 29 条）
反应条件
1: With sodium tetrahydroborate in tetrahydrofuran 2: With boron trifluoride diethyl etherate T=-10 - 70°C;
参考文献
Patel, Bhavesh H.; Barrett, Anthony G. M.
Journal of Organic Chemistry, 2012 , vol. 77, # 24 p. 11296 - 11301
反应条件
lithium aluminium tetrahydride; sulfuric acid in tetrahydrofuran; diethyl ether T=20°C; 2.75 h;
参考文献
ASTRAZENECA AB
Patent: WO2004/60882 A1, 2004 ;
Location in patent: Page 41 ;
WO 2004/060882 A1
反应条件
triethylamine in tetrahydrofuran; methanol; BH3-THF; ethyl acetate
参考文献
Deng, Jianghe; Kerns, Jeffrey K.; Jin, Qi; Lin, Guoliang; Lin, Xichen; Lindenmuth, Michael; Neipp, Christopher; Nie, Hong; Thomas, Sonia M.; Widdowson, Katherine L.
Patent: US2009/143372 A1, 2009 ;
US 20090143372 A1
反应条件
1: methanol With iodobenzene; toluene-4-sulfonic acid; sodium sulfate; 3-chloro-benzenecarboperoxoic acid T=0°C; 0.166667 h; Inert atmosphere; 2: 5-bromo-1,3-dihydro-1,3-dioxo-2H-isoindole With 1,8-diazabicyclo[5.4.0]undec-7-ene T=0 - 40°C; Hofmann-type rearrangement; 5 h; Inert atmosphere; regioselective reaction;
参考文献
Moriyama, Katsuhiko; Ishida, Kazuma; Togo, Hideo
Organic Letters, 2012 , vol. 14, # 3 p. 946 - 949
反应条件
1: sodium borohydride; BF3*Et2O / 3 h / Heating 2: 600 mg / DMAP / dimethylformamide / 15 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 50, # 2 p. 199 - 210
反应条件
sulfuric acid; nitric acid
T=0 - 20°C;
参考文献
Chytil, Milan; Engel, Sharon R.; Fang, Qun Kevin; Spear, Kerry L.
Patent: US2010/204214 A1, 2010 ;
Location in patent: Page/Page column 109 ;
反应条件
ammonium hydroxide
T=20°C; 20 h;
参考文献
Maerkl, Gottfried; Gschwendner, Karl; Roetzer, Ingrid; Kreitmeier, Peter
Helvetica Chimica Acta, 2004 , vol. 87, # 4 p. 825 - 844
反应条件
1: With sodium hydroxide; copper(II) sulfate; zinc in water
T=0 - 20°C; 3 h;
2: With hydrogenchloride in water
pH=7;
参考文献
NEUROCRINE BIOSCIENCES, INC.
Patent: WO2005/103039 A1, 2005 ;
Location in patent: Page/Page column 32 ;
WO 2005/103039 A1
参考文献
Dow AgroSciences LLC; Lo, William C.; Hunter, James E.; Watson, Gerald B.; Patny, Akshay; Iyer, Pravin S.; Boruwa, Joshodeep
Patent: US2014/171312 A1, 2014 ;
Location in patent: Page/Page column ;
