2-氟-4-(三氟甲基)苯胺合成路线 (共 8 条)
反应条件
anhydrous sodium hydrogen carbonate; sulfuric acid
参考文献
Sumitomo Chemical Company, Limited
Patent: US5292952 A1, 1994 ;
反应条件
hydrogenchloride in ethanol 1 h; Heating;
参考文献
Fifolt, Michael J.; Olczak, Raymond T.; Mundhenke, Rudolph F.
Journal of Organic Chemistry, 1985 , vol. 50, # 23 p. 4576 - 4582
反应条件
hydrogenchloride; sodium hydrogencarbonate in ethanol; dichloromethane; water
反应条件
1: 82 percent / CHCl3 / 2 h / Ambient temperature 2: 8.7 g / fluoroxytrifluoromethane, AcOH / 8 h 3: 88 percent / HCl / ethanol / 1 h / Heating View Scheme
参考文献
Journal of Organic Chemistry, , vol. 50, # 23 p. 4576 - 4582
反应条件
1: 8.7 g / fluoroxytrifluoromethane, AcOH / 8 h 2: 88 percent / HCl / ethanol / 1 h / Heating View Scheme
参考文献
Journal of Organic Chemistry, , vol. 50, # 23 p. 4576 - 4582
反应条件
tert.-butylnitrite; copper dichloride in acetonitrile
T=0 - 20°C;
参考文献
GLAXO GROUP LIMITED
Patent: WO2008/22994 A1, 2008 ;
Location in patent: Page/Page column 19-20 ;