四氢-2H-吡喃-2-醇合成路线 （共 136 条）
反应条件
nickel
T=70 - 100°C; P=51485.6 - 66195.7 Torr; Hydrogenation;
参考文献
Sharples Chem.Inc.
Patent: US2516337 , 1946 ;
反应条件
(i) Ph3P, (ii) /BRN= 102742/, NaH, DMSO; Multistep reaction;
参考文献
Ohloff,G. et al.
Helvetica Chimica Acta, 1977 , vol. 60, p. 1161 - 1174
反应条件
2.1: dipyridinium dichromate / dichloromethane / 3 h / Molecular sieve
3.1: magnesium / diethyl ether
3.2: Cooling with ice; Reflux
4.1: pyridine / dichloromethane / 20 °C / Inert atmosphere
5.1: 2,2'-azo-bisisobutyronitrile; tri-n-butyl-tin hydride / hexane / 25 °C / Cooling with liquid nitrogen; Sealed tube; UV-irradiation
View Scheme
参考文献
Beckwith, Athelstan L. J.; Schiesser, Carl H.
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 6 p. 1736 - 1743
反应条件
hydrogenchloride in benzene
3 h; Ambient temperature;
参考文献
Ley, Steven V.; Lygo, Barry; Organ, Helen M.; Wonnacott, Anne
Tetrahedron, 1985 , vol. 41, # 18 p. 3825 - 3836
反应条件
1: 88 percent
2: 67 percent / (NH4)2Ce(NO3)6 / acetonitrile; H2O
View Scheme
参考文献
Wilson, Stephen R.; Augelli-Szafran, Corinne E.
Tetrahedron, 1988 , vol. 44, # 13 p. 3983 - 3996
反应条件
1.1: potassium hydride / 18 °C
1.2: 80 percent / tetrahydrofuran / 2 h / Heating
2.1: 99 percent / 4-methylmorpholine N-oxide; tetrapropylammonium perruthenate; molecular sieve 4 Angstroem / CH2Cl2 / 1 h / 18 °C
3.1: 73 percent / tetrahydrofuran; diethyl ether / 0 °C
4.1: 95 percent / molecular sieves 4 Angstroem; 4-methylmorpholine N-oxide; tetrapropylamonnium perruthenate / CH2Cl2 / 4 h / 18 °C
View Scheme
参考文献
Banwell, Martin G.; Hockless, David C. R.; McLeod, Malcolm D.
New Journal of Chemistry, 2003 , vol. 27, # 1 p. 50 - 59
