四氢-2H-吡喃-2-醇合成路线 （共 136 条）
反应条件
triphenylphosphine; diethylazodicarboxylate in tetrahydrofuran
T=20°C; Mitsunobu reaction; 2 h;
参考文献
Azzouz, Rabah; Bischoff, Laurent; Fouquet, Marc-Henri; Marsais, Francis
Synlett, 2005 , # 18 art. no. D17805ST, p. 2808 - 2810
反应条件
1: potassium carbonate
2: Raney nickel; ethanolic KOH-solution / Hydrogenation
View Scheme
参考文献
Glacet; Gaumeton
Bulletin de la Societe Chimique de France, 1955 , p. 225,227
反应条件
1: 85 percent / hydrogen chloride / benzene / 3 h / Ambient temperature
2: 85 percent / 3N aq. natrium hydroxide / 0.5 h / Heating
View Scheme
参考文献
Ley, Steven V.; Lygo, Barry; Organ, Helen M.; Wonnacott, Anne
Tetrahedron, 1985 , vol. 41, # 18 p. 3825 - 3836
反应条件
1: 85 percent / hydrogen chloride / benzene / 3 h / Ambient temperature
2: 85 percent / 3N aq. natrium hydroxide / 0.5 h / Heating
3: 1.) LDA / 1.) THF, -78 deg C, 1 h, 2.) THF, -78 deg C then RT
4: KOtBu / tetrahydrofuran / 1 h / Ambient temperature
View Scheme
参考文献
Ley, Steven V.; Lygo, Barry; Organ, Helen M.; Wonnacott, Anne
Tetrahedron, 1985 , vol. 41, # 18 p. 3825 - 3836
反应条件
1: 85 percent / hydrogen chloride / benzene / 3 h / Ambient temperature
2: 85 percent / 3N aq. natrium hydroxide / 0.5 h / Heating
3: 1.) LDA / 1.) THF, -78 deg C, 1 h, 2.) THF, -78 deg C then RT
4: KOtBu / tetrahydrofuran / 1 h / Ambient temperature
View Scheme
参考文献
Ley, Steven V.; Lygo, Barry; Organ, Helen M.; Wonnacott, Anne
Tetrahedron, 1985 , vol. 41, # 18 p. 3825 - 3836
反应条件
pyridinium p-toluenesulfonate in dichloromethane
T=20°C;
参考文献
Van Chinh, Luu; Hung, Truong Ngoc; Nga, Nguyen Thi; Phong, Le; Huong, Le Mai; Ha, Tran Thi Hong; Kim, Soo Un; Vu, Tran Khac
Letters in Organic Chemistry, 2014 , vol. 11, # 7 p. 534 - 545
反应条件
in tetrahydrofuran
T=0°C;
参考文献
Diez; Nunez; Beneitez; Moro; Marcos; Basabe; Broughton; Urones
Synlett, 2009 , # 3 p. 390 - 394
反应条件
in water
T=45°C; 72 h;
参考文献
Cheng, Elisabeth; Botzem, Jens; Wanner, Martin J.; Burnt, Brigitte E. A.; Koomen, Gerrit-Jan
Tetrahedron, 1996 , vol. 52, # 19 p. 6725 - 6732
反应条件
triphenylphosphine; diethylazodicarboxylate in tetrahydrofuran
T=20°C; Mitsunobu reaction; 2 h;
参考文献
Azzouz, Rabah; Bischoff, Laurent; Fouquet, Marc-Henri; Marsais, Francis
Synlett, 2005 , # 18 art. no. D17805ST, p. 2808 - 2810
反应条件
1: (benzyl)-triphenylphosphonium chloride With potassium tert-butylate in tert-butyl alcohol
T=20°C; 0.5 h;
2: tetrahydropyranyl alcohol in tert-butyl alcohol
T=20°C; 0.5 h;
参考文献
Tamura, Osamu; Mitsuya, Takahiro; Huang, Xin; Tsutsumi, Yoshiyuki; Hattori, Sanae; Ishibashi, Hiroyuki
Journal of Organic Chemistry, 2005 , vol. 70, # 26 p. 10720 - 10725
