4-(2-甲基苯基)-4-氧代丁酸合成路线 (共 8 条)
反应条件
zinc in water; acetic acid 3 h; Ambient temperature;
参考文献
Kameo; Ogawa; Takeshita; Nakaike; Tomisawa; Sota
Chemical and Pharmaceutical Bulletin, 1988 , vol. 36, # 6 p. 2050 - 2060
反应条件
in tetrahydrofuran T=-78 - 20°C; 2 h;
参考文献
Daval, Sandrine B.; Valant, Celine; Bonnet, Dominique; Kellenberger, Esther; Hibert, Marcel; Galzi, Jean-Luc; Ilien, Brigitte
Journal of Medicinal Chemistry, 2012 , vol. 55, # 5 p. 2125 - 2143
反应条件
in toluene 2 h; Ambient temperature;
参考文献
Astles, Peter C.; Brealey, Clive; Brown, Thomas J.; Facchini, Vincenzo; Handscombe, Caroline; Harris, Neil V.; McCarthy, Clive; McLay, Iain M.; Porter, Barry; Roach, Alan G.; Sargent, Carol; Smith, Christopher; Walsh, Roger J. A.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 15 p. 2732 - 2744
反应条件
2: 73.8 percent / zinc / acetic acid; H2O / 3 h / Ambient temperature View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 36, # 6 p. 2050 - 2060
反应条件
pyridine; diethyl ether Behandeln des Reaktionsgemisches mit wss. Ammoniumchlorid-Loesung bei -10grad;
参考文献
Journal of Organic Chemistry, , vol. 13, p. 592,595
参考文献
Journal of Organic Chemistry, , vol. 15, p. 785,787
反应条件
sulfuric acid
Reflux;
参考文献
Daval, Sandrine B.; Valant, Celine; Bonnet, Dominique; Kellenberger, Esther; Hibert, Marcel; Galzi, Jean-Luc; Ilien, Brigitte
Journal of Medicinal Chemistry, 2012 , vol. 55, # 5 p. 2125 - 2143
反应条件
potassium hydroxide; hydrazine hydrate; 1,2-bis-(2-hydroxyethoxy)-ethane
参考文献
Newman; Cline
Journal of Organic Chemistry, 1951 , vol. 16, p. 934,937