2-(2-碘苯基)-2-丙醇合成路线 （共 23 条）
反应条件
1: methyl iodide With magnesium in diethyl ether
Inert atmosphere;
2: methyl 2-iodobenzoate in diethyl ether
T=0 - 20°C; 1 h; Inert atmosphere;
参考文献
Fan, Yi Chiao; Kwon, Ohyun
Organic Letters, 2012 , vol. 14, # 13 p. 3264 - 3267
反应条件
T=69°C; Decomposition; 3 h; Further byproducts given;
参考文献
Dolenc, Darko; Plesnicar, Bozo
Journal of the American Chemical Society, 1997 , vol. 119, # 11 p. 2628 - 2632
反应条件
tetra-(n-butyl)ammonium iodide; potassium carbonate in acetonitrile
T=20°C; 28 h;
参考文献
Eisenberger, Patrick; Gischig, Sebastian; Togni, Antonio
Chemistry - A European Journal, 2006 , vol. 12, # 9 p. 2579 - 2586
反应条件
in benzene
T=69°C; Decomposition; 3 h;
参考文献
Dolenc, Darko; Plesnicar, Bozo
Journal of the American Chemical Society, 1997 , vol. 119, # 11 p. 2628 - 2632
反应条件
methyl-magnesium iodide; diethyl ether
参考文献
Brown et al.
Journal of the American Chemical Society, 1957 , vol. 79, p. 1906,1909
反应条件
in diethyl ether
T=0 - 20°C; Inert atmosphere;
参考文献
Iwasaki, Masayuki; Iino, Shohei; Nishihara, Yasushi
Organic Letters, 2013 , vol. 15, # 20 p. 5326 - 5329
反应条件
1.1: sulfuric acid
2.1: diethyl ether / 3.5 h / 0 - 20 °C / Inert atmosphere
2.2: Cooling with ice
View Scheme
参考文献
Serra, Stefano
Tetrahedron Asymmetry, 2011 , vol. 22, # 6 p. 619 - 628
反应条件
1: 46 percent / CsF / acetonitrile / 16 h / 20 °C
2: K2CO3; nBu4NI / acetonitrile / 28 h / 20 °C
View Scheme
参考文献
Eisenberger, Patrick; Gischig, Sebastian; Togni, Antonio
Chemistry - A European Journal, 2006 , vol. 12, # 9 p. 2579 - 2586
反应条件
1.1: sulfuric acid; sodium nitrite / water / 0 - 7 °C / |Inert atmosphere
1.2: 1.58 h / -5 - 80 °C / |Inert atmosphere
2.1: diethyl ether / -30 °C / |Inert atmosphere
View Scheme
参考文献
Matousek, Vaclav; Pietrasiak, Ewa; Schwenk, Rino; Togni, Antonio
Journal of Organic Chemistry, 2013 , vol. 78, # 13 p. 6763 - 6768
反应条件
tert-butylhypochlorite
T=20°C; 0.5 h; DarknessInert atmosphere;
参考文献
Fernandez Gonzalez, Davinia; Brand, Jonathan P.; Mondiere, Regis; Waser, Jerome
Advanced Synthesis and Catalysis, 2013 , vol. 355, # 8 p. 1631 - 1639
