二氢-4,4-二甲氧基-2H-吡喃-3(4H)-酮合成路线 (共 4 条)
反应条件
tetrapropylammonium perruthennate; 4 A molecular sieve; 4-methylmorpholine N-oxide in dichloromethane
3 h;
参考文献
MERCK and CO., INC.
Patent: WO2005/105092 A2, 2005 ;
Location in patent: Page/Page column 26 ;
WO 2005/105092 A2
反应条件
1: With dimethyl sulfoxide in dichloromethane
T=0°C; 0.5 h;
2: With triethylamine in dichloromethane
T=20°C;
参考文献
MERCK and CO., INC.
Patent: WO2005/105092 A2, 2005 ;
Location in patent: Page/Page column 27-28 ;
WO 2005/105092 A2
反应条件
1.1: potassium hydroxide / 5 °C
1.2: 0.67 - 0.83 h / 5 °C
1.3: 2 - 2.17 h
2.1: Sodium bromate; RuCl3.3H2O / acetonitrile; water; acetic acid / 2.5 h / 30 °C
View Scheme
参考文献
MERCK SHARP and DOHME CORP.; KUDUK, Scott, D.; CHANG, Ronald, K.; GRESHOCK, Thomas, J.
Patent: WO2011/25851 A1, 2011 ;
WO 2011/025851 A1
反应条件
1.1: (S)-3,3-diphenyl-1-methyltetrahydro-1H,3H-pyrrolo[1,2-c][1,3,2]oxazaborol; dimethylsulfide borane complex / tetrahydrofuran / 25 h / 40 °C / |Inert atmosphere
2.1: potassium tert-butylate / tetrahydrofuran / 0.75 h / 0 °C / |Inert atmosphere
2.2: 2.25 h / 0 - 20 °C
3.1: hydrogenchloride; water / tetrahydrofuran / 2.25 h / 0 - 3 °C
View Scheme
参考文献
JANSSEN PHARMACEUTICA NV; WINTERS, Michael P.; BRANUM, Shawn; FAWZY, Nagy E.; KANG, Fu-An; REUMAN, Michael; RUSSELL, Ronald K.; SUI, Zhihua; TELEHA, Christopher A.
Patent: WO2013/152269 A1, 2013 ;