1: With isopropylmagnesium chloride in tert-butyl methyl ether
T=0°C;
2: With sulfur dioxide in ethylene glycol dimethyl ether; tert-butyl methyl ether
T=40°C; 1 h;
3: With hydrogenchloride; N-chloro-succinimide
more than 3 stages;
参考文献
MEDIVIR AB
Patent: WO2007/144379 A1, 2007 ;
Location in patent: Page/Page column 54-55 ;
