potassium hydroxide in ethanol; water Heating / reflux;

1: With water; potassium hydroxide in ethanol 1 h; Reflux; 2: With hydrogenchloride in ethanol; water

1.1: zinc(II) chloride / diethyl ether; methanol / 7.5 h / 75 - 115 °C / Inert atmosphere 2.1: caesium carbonate / 1-methyl-pyrrolidin-2-one / 20 h / 60 °C / Inert atmosphere 3.1: nitric acid / chloroform / 1 h / -15 - 0 °C 4.1: boron trichloride / dichloromethane / 0.5 h / -15 °C / Inert atmosphere 4.2: Cooling with ice 5.1: 4-(N,N-dimethlyamino)pyridine; triethylamine / dichloromethane / 0.83 h / 0 °C / Inert atmosphere 6.1: potassium fluoride; sodium bromide / tetrakis(triphenylphosphine) palladium(0) / toluene; water / 18 h / 100 °C / Inert atmosphere 7.1: hydrogenchloride; hydrogen / palladium 10 on activated carbon / ethyl acetate; water / 16 h / 21 °C 8.1: triethylamine / dichloromethane / 2 h / 0 °C / Cooling with ice 9.1: potassium hydroxide; water / ethanol / 1 h / Reflux View Scheme

1.1: zinc(II) chloride / diethyl ether; methanol / 7.5 h / 75 - 115 °C / Inert atmosphere 2.1: caesium carbonate / 1-methyl-pyrrolidin-2-one / 20 h / 60 °C / Inert atmosphere 3.1: nitric acid / chloroform / 1 h / -15 - 0 °C 4.1: boron trichloride / dichloromethane / 0.5 h / -15 °C / Inert atmosphere 4.2: Cooling with ice 5.1: 4-(N,N-dimethlyamino)pyridine; triethylamine / dichloromethane / 0.83 h / 0 °C / Inert atmosphere 6.1: potassium fluoride; sodium bromide / tetrakis(triphenylphosphine) palladium(0) / toluene; water / 18 h / 100 °C / Inert atmosphere 7.1: hydrogenchloride; hydrogen / palladium 10 on activated carbon / ethyl acetate; water / 16 h / 21 °C 8.1: triethylamine / dichloromethane / 2 h / 0 °C / Cooling with ice 9.1: potassium hydroxide; water / ethanol / 1 h / Reflux View Scheme

1.1: caesium carbonate / 1-methyl-pyrrolidin-2-one / 20 h / 60 °C / Inert atmosphere 2.1: nitric acid / chloroform / 1 h / -15 - 0 °C 3.1: boron trichloride / dichloromethane / 0.5 h / -15 °C / Inert atmosphere 3.2: Cooling with ice 4.1: 4-(N,N-dimethlyamino)pyridine; triethylamine / dichloromethane / 0.83 h / 0 °C / Inert atmosphere 5.1: potassium fluoride; sodium bromide / tetrakis(triphenylphosphine) palladium(0) / toluene; water / 18 h / 100 °C / Inert atmosphere 6.1: hydrogenchloride; hydrogen / palladium 10 on activated carbon / ethyl acetate; water / 16 h / 21 °C 7.1: triethylamine / dichloromethane / 2 h / 0 °C / Cooling with ice 8.1: potassium hydroxide; water / ethanol / 1 h / Reflux View Scheme

1: 4-(N,N-dimethlyamino)pyridine; triethylamine / dichloromethane / 0.83 h / 0 °C / Inert atmosphere 2: potassium fluoride; sodium bromide / tetrakis(triphenylphosphine) palladium(0) / toluene; water / 18 h / 100 °C / Inert atmosphere 3: hydrogenchloride; hydrogen / palladium 10 on activated carbon / ethyl acetate; water / 16 h / 21 °C 4: triethylamine / dichloromethane / 2 h / 0 °C / Cooling with ice 5: potassium hydroxide; water / ethanol / 1 h / Reflux View Scheme

1: potassium fluoride; sodium bromide / tetrakis(triphenylphosphine) palladium(0) / toluene; water / 18 h / 100 °C / Inert atmosphere 2: hydrogenchloride; hydrogen / palladium 10 on activated carbon / ethyl acetate; water / 16 h / 21 °C 3: triethylamine / dichloromethane / 2 h / 0 °C / Cooling with ice 4: potassium hydroxide; water / ethanol / 1 h / Reflux View Scheme

1: hydrogenchloride; hydrogen / palladium 10 on activated carbon / ethyl acetate; water / 16 h / 21 °C 2: triethylamine / dichloromethane / 2 h / 0 °C / Cooling with ice 3: potassium hydroxide; water / ethanol / 1 h / Reflux View Scheme

1.1: nitric acid / chloroform / 1 h / -15 - 0 °C 2.1: boron trichloride / dichloromethane / 0.5 h / -15 °C / Inert atmosphere 2.2: Cooling with ice 3.1: 4-(N,N-dimethlyamino)pyridine; triethylamine / dichloromethane / 0.83 h / 0 °C / Inert atmosphere 4.1: potassium fluoride; sodium bromide / tetrakis(triphenylphosphine) palladium(0) / toluene; water / 18 h / 100 °C / Inert atmosphere 5.1: hydrogenchloride; hydrogen / palladium 10 on activated carbon / ethyl acetate; water / 16 h / 21 °C 6.1: triethylamine / dichloromethane / 2 h / 0 °C / Cooling with ice 7.1: potassium hydroxide; water / ethanol / 1 h / Reflux View Scheme

1.1: boron trichloride / dichloromethane / 0.5 h / -15 °C / Inert atmosphere 1.2: Cooling with ice 2.1: 4-(N,N-dimethlyamino)pyridine; triethylamine / dichloromethane / 0.83 h / 0 °C / Inert atmosphere 3.1: potassium fluoride; sodium bromide / tetrakis(triphenylphosphine) palladium(0) / toluene; water / 18 h / 100 °C / Inert atmosphere 4.1: hydrogenchloride; hydrogen / palladium 10 on activated carbon / ethyl acetate; water / 16 h / 21 °C 5.1: triethylamine / dichloromethane / 2 h / 0 °C / Cooling with ice 6.1: potassium hydroxide; water / ethanol / 1 h / Reflux View Scheme