1-甲基-1H-吲哚-7-甲醛合成路线 （共 9 条）
反应条件
1: 1H-indole-7-carboxaldehyde With potassium tert-butylate in N,N-dimethyl-formamide
0.333333 h; Inert atmosphere;
2: methyl iodide in N,N-dimethyl-formamide
T=20°C; 12 h;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH
Patent: US2011/269737 A1, 2011 ;
Location in patent: Page/Page column 40 ;
US 20110269737 A1
反应条件
sodium hydride; mineral oil in N,N-dimethyl-formamide
T=0 - 20°C; 0.5 h;
参考文献
Engler, Thomas A.; Furness, Kelly; Malhotra, Sushant; Diefenbacher, Clive; Clayton, Joshua R.
Tetrahedron Letters, 2003 , vol. 44, # 14 p. 2903 - 2905
反应条件
sodium hydroxide in ethanol
2 h; Heating;
参考文献
Etman, H. A.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1995 , vol. 34, # 4 p. 285 - 288
反应条件
1: tetrahydrofuran / 40 °C
2: sodium hydride
3: n-butyllithium
View Scheme
参考文献
Deally, Anthony; Gleeson, Brendan; Mueller-Bunz, Helge; Patil, Siddappa; O'Shea, Donal F.; Tacke, Matthias
Journal of Organometallic Chemistry, 2011 , vol. 696, # 5 p. 1072 - 1083
反应条件
1: tetrahydrofuran / -40 - 20 °C
2: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C
View Scheme
参考文献
Lo, Ho Yin; Nemoto, Peter A.; Kim, Jin Mi; Hao, Ming-Hong; Qian, Kevin C.; Farrow, Neil A.; Albaugh, Daniel R.; Fowler, Danielle M.; Schneiderman, Richard D.; Michael August; Martin, Leslie; Hill-Drzewi, Melissa; Pullen, Steven S.; Takahashi, Hidenori; De Lombaert, Stephane
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 15 p. 4533 - 4539
反应条件
1: toluene-4-sulfonic acid / toluene / Reflux
2: tetrahydrofuran / -40 - 20 °C
3: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C
View Scheme
参考文献
Lo, Ho Yin; Nemoto, Peter A.; Kim, Jin Mi; Hao, Ming-Hong; Qian, Kevin C.; Farrow, Neil A.; Albaugh, Daniel R.; Fowler, Danielle M.; Schneiderman, Richard D.; Michael August; Martin, Leslie; Hill-Drzewi, Melissa; Pullen, Steven S.; Takahashi, Hidenori; De Lombaert, Stephane
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 15 p. 4533 - 4539
反应条件
1: sodium hydride
2: n-butyllithium
View Scheme
参考文献
Deally, Anthony; Gleeson, Brendan; Mueller-Bunz, Helge; Patil, Siddappa; O'Shea, Donal F.; Tacke, Matthias
Journal of Organometallic Chemistry, 2011 , vol. 696, # 5 p. 1072 - 1083
反应条件
1: 7-bromo-1-methylindole With n-butyllithium
2: N,N-dimethyl-formamide
参考文献
Deally, Anthony; Gleeson, Brendan; Mueller-Bunz, Helge; Patil, Siddappa; O'Shea, Donal F.; Tacke, Matthias
Journal of Organometallic Chemistry, 2011 , vol. 696, # 5 p. 1072 - 1083
反应条件
sodium tetrahydroborate; ethanol
T=0 - 20°C; 2 h;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH
Patent: US2011/269737 A1, 2011 ;
Location in patent: Page/Page column 40 ;
US 20110269737 A1
