FAS; ethylenediaminetetraacetic acid; 6,7-dimethyltetrahydropterin; phosphate buffer; oxygen in water T=20°C; pH=7.4; 2 h;

potassium hydroxide; sodium hydroxide in butan-1-ol 24 h; Heating; Yield given;

1: benzene / 2 h / Ambient temperature 2: AlCl3 / various solvent(s) / 20 h / Ambient temperature 3: 1 N NaOH / ethanol; H2O / 0.17 h / Heating 4: hydrazine hydrate, NaOCH3 / 2-methoxy-ethanol / 1.) from 60 deg C to 150 deg C, 2.) 150 deg C, 1 h 5: pyridine hydrochloride / 3 h / 180 °C 6: NaOH, KOH / butan-1-ol / 24 h / Heating View Scheme

1: pyridine hydrochloride / 3 h / 180 °C 2: NaOH, KOH / butan-1-ol / 24 h / Heating View Scheme

1: oxalyl chloride 2: P/HI 3: NaNO2; Cu(NO3)2/Cu2O 4: NaOH View Scheme

1: NaNO2; Cu(NO3)2/Cu2O 2: NaOH View Scheme

1: P/HI 2: NaNO2; Cu(NO3)2/Cu2O 3: NaOH View Scheme

1: NaNO2; KI 2: xylene / Heating 3: oxalyl chloride 4: P/HI 5: NaNO2; Cu(NO3)2/Cu2O 6: NaOH View Scheme