2-[(2,6-二氯苯基)氨基]-5-羟基苯乙酸合成路线 （共 17 条）
反应条件
sodium hydrogensulfite in water; acetonitrile Electrolysis;
参考文献
Stalder, Romain; Roth, Gregory P.
ACS Medicinal Chemistry Letters, 2013 , vol. 4, # 11 p. 1119 - 1123
反应条件
glucose-6-phosphate dehydrogenase; Glc 6P; cytochrome P450 3A4 co-expressed with human P450 oxidoreductase and cytochrome b5; human glutathione-S-transferase P1-1; NADPH in aq. phosphate buffer; dimethyl sulfoxide pH=7.4; 1 h; HeatingEnzymatic reaction;
参考文献
Chemico-Biological Interactions, , vol. 207, # 1 p. 32 - 40
反应条件
sodium hydroxide in ethanol T=80°C; 36 h;
参考文献
Kenny, Jane R.; Maggs, James L.; Meng, Xiaoli; Sinnott, Deborah; Clarke, Stephen E.; Park, B. Kevin; Stachulski, Andrew V.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 11 p. 2816 - 2825
反应条件
glucose-6-phosphate dehydrogenase; Glc 6P; cytochrome P450 3A4 co-expressed with human P450 oxidoreductase and cytochrome b5; human glutathione-S-transferase P1-1; NADPH in aq. phosphate buffer; dimethyl sulfoxide T=37°C; pH=7.4; 1 h; Enzymatic reaction; Reagent/catalystTemperature;
参考文献
Chemico-Biological Interactions, , vol. 207, # 1 p. 32 - 40
反应条件
FAS; ethylenediaminetetraacetic acid; 6,7-dimethyltetrahydropterin; phosphate buffer; oxygen in water T=20°C; pH=7.4; 2 h;
参考文献
Tetrahedron, , vol. 60, # 17 p. 3855 - 3862
反应条件
potassium hydroxide; sodium hydroxide in butan-1-ol 24 h; Heating; Yield given;
参考文献
Journal of Medicinal Chemistry, , vol. 33, # 9 p. 2358 - 2368
反应条件
1: benzene / 2 h / Ambient temperature 2: AlCl3 / various solvent(s) / 20 h / Ambient temperature 3: 1 N NaOH / ethanol; H2O / 0.17 h / Heating 4: hydrazine hydrate, NaOCH3 / 2-methoxy-ethanol / 1.) from 60 deg C to 150 deg C, 2.) 150 deg C, 1 h 5: pyridine hydrochloride / 3 h / 180 °C 6: NaOH, KOH / butan-1-ol / 24 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 33, # 9 p. 2358 - 2368
反应条件
1: 80 percent / N-iodosuccinimide / acetonitrile / 12 h / Heating 2: 91 percent / K2CO3; CuI; Cu / toluene / 24 h / Heating 3: 90 percent / BBr3 / CH2Cl2; 1,2-dichloro-ethane / 20 °C 4: 80 percent / aq. NaOH / ethanol / 36 h / 80 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 47, # 11 p. 2816 - 2825
反应条件
1: 91 percent / K2CO3; CuI; Cu / toluene / 24 h / Heating 2: 90 percent / BBr3 / CH2Cl2; 1,2-dichloro-ethane / 20 °C 3: 80 percent / aq. NaOH / ethanol / 36 h / 80 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 47, # 11 p. 2816 - 2825
反应条件
1: 90 percent / BBr3 / CH2Cl2; 1,2-dichloro-ethane / 20 °C 2: 80 percent / aq. NaOH / ethanol / 36 h / 80 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 47, # 11 p. 2816 - 2825
