3-(4,4-二甲基-4,5-二氢-1,3-氧唑-2-基)吡啶合成路线 （共 33 条）
反应条件
2,2,6,6-tetramethylpiperidinyl-lithium
1.) THF, 0 deg C, 1 h, 2.) 25 deg C, 5 h; Yield given. Multistep reaction;
参考文献
Meyers, A. I.; Gabel, Richard A.
Journal of Organic Chemistry, 1982 , vol. 47, # 13 p. 2633 - 2637
反应条件
water; oxygen
multistep reaction; effects of reaction temperature, reaction time, reactant ratios, and solvent effect; Product distribution;
参考文献
Hauck, Albert E.; Giam, C. S.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , # 10 p. 2227 - 2232
反应条件
1: 82 percent / tetrahydrofuran / 0.17 h / -78 °C
2: 81 percent / sulfur / toluene / 3.5 h / Heating
3: 96 percent / conc. HCl / 16 h / Heating
4: SOCl2 / dimethylformamide / 16 h / Heating
5: N,N-diisopropylethylamine / CH2Cl2 / 0 - 20 °C
View Scheme
参考文献
Augelli-Szafran, Corinne E.; Blankley, C. John; Jaen, Juan C.; Moreland, David W.; Nelson, Carrie B.; Penvose-Yi, Jan R.; Schwarz, Roy D.; Thomas, Anthony J.
Journal of Medicinal Chemistry, 1999 , vol. 42, # 3 p. 356 - 363
