3,5-二甲基-4-溴碘苯合成路线 （共 5 条）
反应条件
tetrabutylammomium bromide; palladium diacetate; potassium carbonate in water; N,N-dimethyl-formamide; isopropyl alcohol T=115°C; 12 h;
参考文献
Sasaki, Shigeru; Murakami, Fumiki; Murakami, Midori; Watanabe, Mariko; Kato, Kiyotoshi; Sutoh, Katsuhide; Yoshifuji, Masaaki
Journal of Organometallic Chemistry, 2005 , vol. 690, # 10 p. 2664 - 2672
反应条件
1: With sulfuric acid; sodium nitrite in water
T=-10°C; 0.416667 h; Inert atmosphere;
2: With potassium iodide in water
T=-10 - 0°C; 2.33 h; Inert atmosphere;
参考文献
Fujihara, Tetsuaki; Tomike, Yoshikazu; Ohtake, Toshiyuki; Terao, Jun; Tsuji, Yasushi
Chemical Communications, 2011 , vol. 47, # 34 p. 9699 - 9701
反应条件
1.1: 80 percent / aq. NaOH / ethanol / 6 h / Heating
2.1: conc. HCl; NaNO2 / H2O / 0.5 h / cooling
2.2: KI / H2O / 0.75 h / Heating
View Scheme
参考文献
Rodriguez, Gema; Albrecht, Martin; Schoenmaker, Jeroen; Ford, Alan; Lutz, Martin; Spek, Anthony L.; Van Koten, Gerard
Journal of the American Chemical Society, 2002 , vol. 124, # 18 p. 5127 - 5138
反应条件
1.1: acetic acid
1.2: 88 percent / Br2 / acetic acid / cooling
2.1: 80 percent / aq. NaOH / ethanol / 6 h / Heating
3.1: conc. HCl; NaNO2 / H2O / 0.5 h / cooling
3.2: KI / H2O / 0.75 h / Heating
View Scheme
参考文献
Rodriguez, Gema; Albrecht, Martin; Schoenmaker, Jeroen; Ford, Alan; Lutz, Martin; Spek, Anthony L.; Van Koten, Gerard
Journal of the American Chemical Society, 2002 , vol. 124, # 18 p. 5127 - 5138
反应条件
palladium diacetate; sodium carbonate; triphenylphosphine; 3,4,5-trimethoxyphenylboronic acid in water; acetone
18 h; RefluxInert atmosphere;
参考文献
Fujihara, Tetsuaki; Tomike, Yoshikazu; Ohtake, Toshiyuki; Terao, Jun; Tsuji, Yasushi
Chemical Communications, 2011 , vol. 47, # 34 p. 9699 - 9701
