2-甲基-4-甲氧基吡啶-N-物合成路线 （共 16 条）
反应条件
trimethylamine-sulphur dioxide complex in 1,4-dioxane 2.5 h; Heating;
参考文献
Olah, George A.; Arvanaghi, Massoud; Vankar, Yashwant D.
Synthesis, 1980 , # 8 p. 660 - 661
反应条件
1: acetic anhydride 2: thionyl chloride View Scheme
参考文献
Kuehler, Thomas C.; Swanson, Marianne; Shcherbuchin, Vladimir; Larsson, Hakan; Mellgard, Bjoern; Sjoestroem, Jan-Eric
Journal of Medicinal Chemistry, 1998 , vol. 41, # 11 p. 1777 - 1788
反应条件
1: zinc; sulfuric acid; water 2: water; acetic acid / 200 °C 3: potassium hydroxide View Scheme
参考文献
Profft
Archiv der Pharmazie (Weinheim, Germany), 1958 , vol. 291, p. 429,434
反应条件
1: acetic acid anhydride / Erwaermen des Reaktionsprodukts mit wss.Salzsaeure 2: selenium dioxide; dioxane / 80 °C View Scheme
参考文献
Furukawa
Yakugaku Zasshi, 1957 , vol. 77, p. 11,13
Chem.Abstr., 1957 , p. 8745
参考文献
Pfizer Inc.
Patent: US4562197 A1, 1985 ;
参考文献
Kuehler, Thomas C.; Swanson, Marianne; Shcherbuchin, Vladimir; Larsson, Hakan; Mellgard, Bjoern; Sjoestroem, Jan-Eric
Journal of Medicinal Chemistry, 1998 , vol. 41, # 11 p. 1777 - 1788
反应条件
1: With trifluoroacetic anhydride in dichloromethane T=0 - 40°C; 6.83 h; 2: With water; sodium hydrogencarbonate in dichloromethane 1 h;
参考文献
WO2009/56886 A1, ;
Page/Page column 54 ;
WO 2009/056886 A1
反应条件
acetic anhydride Erwaermen des Reaktionsprodukts mit wss.Salzsaeure;
参考文献
Yakugaku Zasshi, , vol. 77, p. 11,13
Chem.Abstr., , p. 8745
反应条件
potassium carbonate
12 h; Heating;
参考文献
Chen, Hongfeng; Sweet, James A.; Lam, Kin-Chung; Rheingold, Arnold L.; McGrath, Dominic V.
Tetrahedron Asymmetry, 2009 , vol. 20, # 14 p. 1672 - 1682
参考文献
Pfizer Inc.
Patent: US4562197 A1, 1985 ;
