N2-异丁酰基-2′-脱氧鸟苷合成路线 （共 30 条）
反应条件
1: L-2'-deoxyguanosine With pyridine; chloro-trimethyl-silane 0.5 h; cooling; 2: 2-methylpropanoic anhydride T=20°C; 2.5 h;
参考文献
Challa, Hemavathi; Bruice, Thomas C.
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 6 p. 1475 - 1481
反应条件
iodine in methanol T=60°C; detritylation;
参考文献
Wahlstrom, Jan L.; Ronald, Robert C.
Journal of Organic Chemistry, 1998 , vol. 63, # 17 p. 6021 - 6022
反应条件
1: L-2'-deoxyguanosine With pyridine; chloro-trimethyl-silane 0.5 h; Cooling with ice bath; 2: isobutyric anhydride T=20°C; 2.5 h; 3: With water; ammonium chloride 0.5 h; Cooling with ice;
参考文献
Glaser, Gad; Katzhendler, Jehoshua; Hilgenfeld, Rolf; Vidavski, Roee; Wexselblatt, Ezequiel; Prez-Menahemov, Tamar; Kaspy, Ilana
Patent: US2011/86813 A1, 2011 ;
Location in patent: Page/Page column 33-34 ;
反应条件
sodium hydroxide in pyridine; methanol 0.00833333 h; microwave irradiation;
参考文献
Rao; Kumar; Chauhan; Garg; Gupta
Nucleosides, Nucleotides and Nucleic Acids, 2002 , vol. 21, # 4-5 p. 393 - 400
反应条件
1: 97 percent / iPr2NEt; DMAP / dimethylformamide / 0.03 h / microwave irradiation 2: 98.5 percent / 0.3 N NaOH / pyridine; methanol / 0.01 h / microwave irradiation View Scheme
参考文献
Nucleosides, Nucleotides and Nucleic Acids, , vol. 21, # 4-5 p. 393 - 400
反应条件
Candida antarctica lipase B; phosphate buffer in 1,4-dioxane T=40°C; pH=7; 14 h;
参考文献
Garcia, Javier; Fernandez, Susana; Ferrero, Miguel; Sanghvi, Yogesh S.; Gotor, Vicente
Journal of Organic Chemistry, 2002 , vol. 67, # 13 p. 4513 - 4519
反应条件
1: pyridine / 2 h 2: aq. NH4OH / pyridine / 0.5 h View Scheme
参考文献
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, , vol. 32, # 9 p. 916 - 919
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran 0.0833333 h; ZnBr2, nitromethane, 10 min.;
参考文献
Gaffney, B. L.; Jones, R. A.
Tetrahedron Letters, 1982 , vol. 23, # 22 p. 2257 - 2260
反应条件
in benzene 1 h; Irradiation;
参考文献
Pirrung, Michael C.; Bradley, Jean-Claude
Journal of Organic Chemistry, 1995 , vol. 60, # 5 p. 1116 - 1117
反应条件
1: With pyridine; chloro-trimethyl-silane T=0 - 20°C; 2: With ammonium hydroxide; water T=0 - 20°C;
参考文献
Kline, Toni; Jackson, Stona R.; Deng, Wei; Verlinde, Christophe L. M. J.; Miller, Samuel I.
Nucleosides, Nucleotides and Nucleic Acids, 2008 , vol. 27, # 12 p. 1282 - 1300
