N2-异丁酰-5'-O-(4,4'-二甲氧基三苯基)-2'-脱氧鸟苷合成路线 （共 21 条）
反应条件
4-(N,N-dimethlyamino)pyridine in 1,4-dioxane; pyridine 2 h;
参考文献
McGee, Danny P. C.; Martin, John C.; Webb, Austin S.
Synthesis, 1983 , # 7 p. 540 - 541
反应条件
1H-imidazole in methanol 72 h; Ambient temperature;
参考文献
Brill, Wolfgang K.-D.
Tetrahedron Letters, 1994 , vol. 35, # 19 p. 3041 - 3044
反应条件
1: pyridine / 0.5 h / 0 °C 2: pyridine / 2 h 3: aq. NH4OH / pyridine / 0.5 h 4: 72 percent / DMAP, TEA / pyridine / 1 h View Scheme
参考文献
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, , vol. 32, # 9 p. 916 - 919
反应条件
1: NaOH / ethanol; H2O / 0.67 h / 0 - 3 °C 2: 84 percent / 1.) pyridine, 0 deg C, 16 h, 2.) pyridine, CH3OH, 20 deg C, 1 h View Scheme
参考文献
Helvetica Chimica Acta, , vol. 65, # 8 p. 2372 - 2393
反应条件
1: 91 percent / pyridine / 3 h / 20 °C 2: lithium triethylborohydride / tetrahydrofuran / 16 h / cooling View Scheme
参考文献
Nucleosides, Nucleotides and Nucleic Acids, , vol. 23, # 1-2 p. 171 - 181
反应条件
1: 85 percent / TBAF / tetrahydrofuran / 2 h / 20 °C 2: 91 percent / pyridine / 3 h / 20 °C 3: lithium triethylborohydride / tetrahydrofuran / 16 h / cooling View Scheme
参考文献
Nucleosides, Nucleotides and Nucleic Acids, , vol. 23, # 1-2 p. 171 - 181
反应条件
1: 61 g / pyridine / 20 °C 2: 40 g / DMAP / CH2Cl2 / 3 h 3: 85 percent / TBAF / tetrahydrofuran / 2 h / 20 °C 4: 91 percent / pyridine / 3 h / 20 °C 5: lithium triethylborohydride / tetrahydrofuran / 16 h / cooling View Scheme
参考文献
Nucleosides, Nucleotides and Nucleic Acids, , vol. 23, # 1-2 p. 171 - 181
反应条件
1: 91 percent / pyridine / 3 h / 20 °C 2: lithium triethylborohydride / tetrahydrofuran / 16 h / cooling View Scheme
参考文献
Nucleosides, Nucleotides and Nucleic Acids, , vol. 23, # 1-2 p. 171 - 181
反应条件
1: 40 g / DMAP / CH2Cl2 / 3 h 2: 85 percent / TBAF / tetrahydrofuran / 2 h / 20 °C 3: 91 percent / pyridine / 3 h / 20 °C 4: lithium triethylborohydride / tetrahydrofuran / 16 h / cooling View Scheme
参考文献
Nucleosides, Nucleotides and Nucleic Acids, , vol. 23, # 1-2 p. 171 - 181
反应条件
1.1: trimethylchlorosilane; pyridine / 1 h / 20 °C 1.2: 20 h 1.3: ammonium hydroxide; pyridine 2.1: 61 g / pyridine / 20 °C 3.1: 40 g / DMAP / CH2Cl2 / 3 h 4.1: 85 percent / TBAF / tetrahydrofuran / 2 h / 20 °C 5.1: 91 percent / pyridine / 3 h / 20 °C 6.1: lithium triethylborohydride / tetrahydrofuran / 16 h / cooling View Scheme
参考文献
Nucleosides, Nucleotides and Nucleic Acids, , vol. 23, # 1-2 p. 171 - 181
