4-氯-5-氮杂吲哚-2-甲酸甲酯合成路线 （共 4 条）
反应条件
copper(l) iodide; potassium carbonate; L-proline in 1,4-dioxane Inert atmosphereReflux;
参考文献
MERCK SHARP and DOHME CORP.; HANNEY, Barbara; MANLEY, Peter; RUDD, Michael, T.; SANDERS, John, M.; STACHEL, Shawn, J.; HENZE, Darrell
Patent: WO2013/9582 A1, 2013 ;
Location in patent: Page/Page column 29; 30 ;
反应条件
in 1,3,5-trimethyl-benzene Hemetsberger-Knittel reaction; 1 h; Heating;
参考文献
Roy, Patrick J.; Dufresne, Claude; Lachance, Nicolas; Leclerc, Jean-Philippe; Boisvert, Michel; Wang, Zhaoyin; Leblanc, Yves
Synthesis, 2005 , # 16 art. no. M03305SS, p. 2751 - 2757
反应条件
1: 63 percent / NaOMe / methanol / -10 - 0 °C 2: 72 percent / 1,3,5-trimethyl-benzene / 1 h / Heating View Scheme
参考文献
Synthesis, , # 16 art. no. M03305SS, p. 2751 - 2757
反应条件
1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 0.5 h / 20 °C 1.2: 4 h / 20 °C / |Cooling 2.1: potassium carbonate; copper(l) iodide; L-proline / 1,4-dioxane / |Inert atmosphere; |Reflux View Scheme
