反应条件
1: 5.5 g / Et3N / diethyl ether / 3 h 2: 1.) oxalyl chloride, DMSO, 2.) Et3N / 1.) CH2Cl2, 20 min, 2.) CH2Cl2, 20 min 3: 48 percent / H2, 48 percent HBF4 / Raney Ni / ethanol / 6 h / 760 Torr 4: 870 mg / LiAlH4 / tetrahydrofuran / 1 h / 0 °C View Scheme
参考文献
Kempf, Dale J.; Sham, Hing L.; Marsh, Kennan C.; Flentge, Charles A.; Betebenner, David; Green, Brian E.; McDonald, Edith; Vasavanonda, Sudthida; Saldivar, Ayda; Wideburg, Norman E.; Kati, Warren M.; Ruiz, Lisa; Zhao, Chen; Fino, Lynnmarie; Patterson, Jean; Molla, Akhteruzzaman; Plattner, Jacob J.; Norbeck, Daniel W.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 4 p. 602 - 617
