5-甲基噻唑-4-甲酸甲酯合成路线 （共 11 条）
反应条件
tert.-butylnitrite in tetrahydrofuran
参考文献
TAKEDA PHARMACEUTICAL COMPANY LIMITED
Patent: US2009/137595 A1, 2009 ;
反应条件
in toluene T=80°C; 46 h;
参考文献
Journal of the American Chemical Society, , vol. 100, p. 8214 - 8222
反应条件
in toluene T=80°C; 48 h;
参考文献
Irving, James R.; Perrone, Ettore; Stoodley, Richard J.
Tetrahedron Letters, 1983 , vol. 24, # 24 p. 2501 - 2504
反应条件
Lawesson's reagent in tetrahydrofuran Heating;
参考文献
Davies, James R.; Kane, Peter D.; Moody, Christopher J.
Tetrahedron, 2004 , vol. 60, # 18 p. 3967 - 3977
反应条件
1: 43 percent / Rh2(OAc)4 / 1,2-dichloro-ethane / Heating 2: 60 percent / Lawesson's reagent / tetrahydrofuran / Heating View Scheme
参考文献
Tetrahedron, , vol. 60, # 18 p. 3967 - 3977
参考文献
Irving, James R.; Perrone, Ettore; Stoodley, Richard J.
Tetrahedron Letters, 1983 , vol. 24, # 24 p. 2501 - 2504
反应条件
1: 1.) 2,6-lutidine, thionyl chloride, 2.) silica gel / 1.) THF, -30 deg C, 0 deg C, 2.) THF, 15 h 2: 75 percent / toluene / 48 h / 80 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 24, # 24 p. 2501 - 2504
反应条件
1: 1.) O3, 2.) Me2CO2H-Zn / 1.) CH2Cl2, -78 deg C 2: 1.) 2,6-lutidine, thionyl chloride, 2.) silica gel / 1.) THF, -30 deg C, 0 deg C, 2.) THF, 15 h 3: 75 percent / toluene / 48 h / 80 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 24, # 24 p. 2501 - 2504
反应条件
1: 1.) 2,6-lutidine, thionyl chloride, 2.) silica gel / 1.) THF, -30 deg C, 0 deg C, 2.) THF 2: 70 percent / 96 h / 80 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 24, # 24 p. 2501 - 2504
反应条件
1: 1.) O3, 2.) Me2CO2H-Zn / 1.) CH2Cl2, -78 deg C 2: 1.) 2,6-lutidine, thionyl chloride, 2.) silica gel / 1.) THF, -30 deg C, 0 deg C, 2.) THF 3: 70 percent / 96 h / 80 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 24, # 24 p. 2501 - 2504
